Characterization of three different beta-lactamases from the Bacteroides fragilis group.

Antimicrobial Agents and Chemotherapy
B Olsson-LiljequistC E Nord

Abstract

beta-Lactamases from five strains of Bacteroides fragilis and two strains of Bacteroides uniformis, all resistant to beta-lactam antibiotics, were compared by means of isoelectric focusing and enzyme kinetic measurements. beta-Lactamases from the five B. fragilis strains were identical, whereas those from the two B. uniformis strains were distinguished from each other and also from the B. fragilis enzymes. The two B. uniformis strains were relatively resistant to cefoxitin (minimal inhibitory concentration, 32 micrograms/ml), but only one of the strains, B. uniformis 2986, was found to rapidly inactivate cefoxitin. This apparently enzymatic inactivation of cefoxitin seemed to be of minor importance, and the main factor for cefoxitin resistance was considered to be a decreased permeability of the drug. Transfer of resistance to beta-lactam antibiotics from these beta-lactamase-producing strains of B. fragilis and B. uniformis to a non-beta-lactamase-producing strain of Bacteroides distasonis was attempted, but with these isolates no transfer of resistance to beta-lactam antibiotics was demonstrated.

References

May 1, 1976·Antimicrobial Agents and Chemotherapy·B OlssonT Wadström
Mar 1, 1978·Antimicrobial Agents and Chemotherapy·M L Britz, R G Wilkinson
Feb 1, 1979·Antimicrobial Agents and Chemotherapy·L A Eriquez, R F D'Amato
Jan 1, 1979·The Journal of Infectious Diseases·G PriviteraM Sebald
Oct 7, 1977·Medical Microbiology and Immunology·B OlssonC E Nord
Oct 1, 1977·The Journal of Infectious Diseases·C Mancini, R J Behme
Feb 1, 1979·Antimicrobial Agents and Chemotherapy·B OlssonC E Nord
Jan 1, 1979·The Journal of Infectious Diseases·F P TallyM H Malamy
Apr 1, 1979·Plasmid·R A WelchF L Macrina
Jan 1, 1975·Biochimie·F Le GofficR Letarte
Oct 1, 1975·Journal of Bacteriology·D G Guiney, C E Davis
Jan 1, 1974·Antimicrobial Agents and Chemotherapy·H R OnishiE O Stapley
Jul 15, 1972·FEBS Letters·J SöderholmT Wadström

❮ Previous
Next ❯

Citations

Nov 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C V Sanders, K E Aldridge
Dec 1, 1986·European Journal of Clinical Microbiology·B O Liljequist, L Gezelius
Jan 1, 1982·Indian Journal of Pediatrics·H Thadepalli
May 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E LindhA Forsgren
Jun 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·K Jalakas-PörnullU Broberger
Dec 1, 1983·Antimicrobial Agents and Chemotherapy·A YotsujiS Mitsuhashi
Jun 1, 1985·Antimicrobial Agents and Chemotherapy·K TunérC E Nord
Nov 1, 1986·Antimicrobial Agents and Chemotherapy·F MalouinJ M Lacroix
Mar 1, 1989·Antimicrobial Agents and Chemotherapy·K Bush
Apr 1, 1994·Antimicrobial Agents and Chemotherapy·K E AldridgeD D Schiro
Jun 1, 1995·Antimicrobial Agents and Chemotherapy·K BushA A Medeiros
Jul 1, 1995·Antimicrobial Agents and Chemotherapy·M HedbergC E Nord
Apr 1, 1982·International Journal of Oral Surgery·H Bystedt, C E Nord
Oct 1, 1981·International Journal of Oral Surgery·L von KonowA Nordenram
Feb 1, 1988·The British Journal of Oral & Maxillofacial Surgery·I A IatrouA Patrikiou
Feb 1, 1996·Journal of Chemotherapy·M Hedberg, C E Nord
Oct 1, 1995·Clinical Microbiology Reviews·D M Livermore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.