PMID: 8951928Oct 1, 1996Paper

Characterization of time course of spinal amino acids, citrulline and PGE2 release after carrageenan/kaolin-induced knee joint inflammation: a chronic microdialysis study

Pain
L C YangTony L Yaksh

Abstract

Pharmacological studies have implicated the spinal activation of excitatory amino acids, nitric oxide, and prostaglandins systems in the development of tactile and thermal hypersensitivity and central sensitization after peripheral inflammation. In the present study, using a chronically placed loop dialysis catheter, we examined in the unanesthetized rat the effect of carrageenan/kaolin (C/K)-induced knee joint inflammation on the time course of spinal release of several active factors including excitatory amino acids (glutamate, aspartate), citrulline (a marker of nitric oxide formation), and prostaglandin E2 (PGE2) as well as the concomitant development of tactile and thermal hypersensitivity. Infection of C/K in the knee evoked a significant release of glutamate, with an initial peak seen immediately after knee C/K injection (179 +/- 22%) and with a progressive and consistent increase over a period of 24 h (153-186%). Comparable changes in the concentration of aspartate (123-179%) were observed. Citrulline was constantly above baseline for the 24-h period (121-158%). PGE2 was significantly increased at 10 min (146 +/- 11%) with no change observed between 3-5 h. At 24 h, PGE2 was again significantly (143 +/- 18%) increased. B...Continue Reading

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Citations

Jan 25, 2003·Brain Research·Josélia Borba Daher, Carlos Rogério Tonussi
Aug 26, 2003·Advanced Drug Delivery Reviews·Carl-Olav StillerErnst Brodin
Mar 29, 2001·Progress in Neurobiology·H Vanegas, H G Schaible
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jan 24, 2007·The Journal of Experimental Medicine·Camilla I SvenssonCharles N Serhan
Jan 25, 2002·Annual Review of Pharmacology and Toxicology·Camilla I Svensson, Tony L Yaksh
Jan 7, 2005·Biological & Pharmaceutical Bulletin·In-Tae KimKyung-Tae Lee
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·T L YakshM Marsala
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J SmithP C Isakson
Mar 8, 2002·The Journal of Physiology·Stephanie L BorglandMacDonald J Christie
Oct 27, 2004·The Journal of Pain : Official Journal of the American Pain Society·Seiji OhtoriHideshige Moriya
Sep 5, 2006·The Journal of Pain : Official Journal of the American Pain Society·Fei-Yu ZhangKai-Yuan Fu
Feb 25, 2003·British Journal of Pharmacology·Takae IbukiTony L Yaksh
May 8, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Y Kuraishi, F Ushikubi

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