Characterization of tissue effects produced by the Prolase II lateral-firing neodymium:YAG laser fiber in the canine prostate

Lasers in Surgery and Medicine
H S GillP W Mikus

Abstract

The immediate and long term-effects of neodymium:YAG laser treatment with the ProLase II lateral-firing laser fiber in the canine prostate were evaluated. Fourteen male dogs, aged 3 years and older with established benign prostatic hyperplasia, underwent endoscopic ablation of the prostate using the ProLase II fiber. Subjects were treated at laser power settings of 60 watts (6 dogs), 75 watts (4 dogs), or 90 watts (3 dogs), with a mean total energy delivery of 15,000 joules. One dog underwent a sham procedure and served as a normal control. Prostates were examined grossly and histologically at 48 hours, 2 weeks, 4 weeks, or 8 weeks post-treatment. The cross-sectional diameter and volume of tissue ablation were measured in each prostate. Histological studies of the extent of thermal injury to the prostatic tissue and the course of healing of the prostatic urethra were performed. The mean cross-sectional diameter of tissue ablation was 28.6 +/- 4.7 mm and mean volume of tissue ablation was 8.2 +/- 5.1 cc. No statistically significant difference in diameter or volume of tissue ablation was noted between varying power settings. Histological studies showed extensive tissue necrosis with hemorrhage and an acute inflammatory cell infi...Continue Reading

Citations

Jan 1, 1996·Lasers in Surgery and Medicine·J N Kabalin
Jan 1, 1994·Lasers in Surgery and Medicine·J N Kabalin, H S Gill
Oct 1, 1996·Journal of Endourology·J N Kabalin
Aug 14, 1998·Mayo Clinic Proceedings·R S KuntzmanD M Barrett
Jul 1, 1999·Journal of Biomedical Optics·D D Royston, P Q Richards
Dec 9, 2008·Physics in Medicine and Biology·S A van NimwegenJ Kirpensteijn

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