PMID: 8956374Nov 1, 1996Paper

Characterization of tobacco withdrawal symptoms: transdermal nicotine reduces hunger and weight gain

Psychopharmacology
Douglas E JorenbyTimothy B Baker

Abstract

The accurate assessment of both tobacco withdrawal and the impact of the nicotine patch on withdrawal may be compromised by attrition of subjects, or by subjects smoking during withdrawal. To reduce these occurrences, 211 participants were provided with intensive cessation counseling while trying to quit smoking with either nicotine (21 mg) or placebo transdermal patches. Subject attrition was low, with 80.5% of participants continuing through the 5-week study period. Abstinence rates were also high over this period (75% and 61% in active and placebo groups, respectively). In this multisite, double-blind trial, withdrawal severity was assessed using a nine-item daily self-report questionnaire, and abstinence was confirmed via CO monitoring. Abrupt smoking cessation increased multiple tobacco withdrawal symptoms/signs including craving for cigarettes, irritability, anxiety, appetite, sleep disruption, difficulty concentrating, restlessness, depression, and impatience. Treatment with transdermal nicotine reduced craving for cigarettes, anxiety, irritability, and appetite, as well as weight gain (1.85 versus 2.88 kg mean gain over 4 weeks in active and placebo groups, respectively).

Citations

Jul 26, 2011·Journal of Immigrant and Minority Health·Sun S KimDouglas Ziedonis
Nov 14, 2007·Clinical Reviews in Allergy & Immunology·Andrea T BorchersM Eric Gershwin
Nov 5, 2005·Brain Research. Brain Research Reviews·Adrie W Bruijnzeel, Mark S Gold
Jul 26, 2003·Appetite·Patrick Frankham, Michel Cabanac
Jul 5, 2001·Addictive Behaviors·M M WardL M Jack
Apr 25, 2000·Drug and Alcohol Dependence·S M ColbyR S Niaura
May 4, 2002·American Journal of Preventive Medicine·David GonzalesRichard D Hurt
Jan 1, 1997·Journal of Substance Abuse·J R Hughes, D K Hatsukami
Mar 26, 2003·Journal of Abnormal Psychology·Thomas M PiaseckiTimothy B Baker
Apr 26, 2000·Journal of Consulting and Clinical Psychology·S T TiffanyC A Elash
Jun 15, 2007·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Benjamin A TollSuchitra Krishnan-Sarin
Nov 6, 2003·Experimental and Clinical Psychopharmacology·Thomas M PiaseckiTimothy B Baker
Jun 8, 2006·Experimental and Clinical Psychopharmacology·Sarah E EvansThomas Eissenberg
Feb 14, 2007·Experimental and Clinical Psychopharmacology·Damaris J RohsenowGary B Kaplan
Mar 4, 1999·The New England Journal of Medicine·D E JorenbyT B Baker
Nov 22, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Bess H MarcusDavid B Abrams
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·B L NordstromA J Garvey
Jan 5, 2002·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·M L Stitzer
May 9, 2009·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rinka M P Van ZundertRutger C M E Engels
May 26, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Xin YuChen Wang
May 23, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jonathan FouldsJohn R Hughes
Mar 12, 2008·Addiction Biology·Carmen GómezRosa Redolat
Apr 24, 2003·Occupational and Environmental Medicine·F Rodríguez-ArtalejoJ R Banegas
Jan 28, 2004·Annual Review of Psychology·Timothy B BakerLaurie Chassin
Apr 29, 2010·Clinical Trials : Journal of the Society for Clinical Trials·Brian L EglestonCarolyn J Heckman
Jun 27, 2003·Journal of Perinatal Medicine·A Michael ToschkeScott M Montgomery
Jul 31, 2001·CNS Drugs·K A Perkins
Dec 2, 2004·Experimental and Clinical Psychopharmacology·Sheila M AlessiStephen T Higgins
Feb 6, 2004·Psychological Review·Timothy B BakerMichael C Fiore
Mar 24, 2005·Psychological Review·David J KavanaghJon May
Feb 13, 2009·Issues in Mental Health Nursing·Sun S KimElsie E Gulick
Jul 5, 2005·Expert Opinion on Investigational Drugs·D Gurwitz
Jun 23, 2005·Current Medical Research and Opinion·Joseph C CappelleriDavid G Gilbert
Mar 13, 2012·Neuroscience and Biobehavioral Reviews·Adrie W Bruijnzeel
Dec 8, 2009·Neuroscience and Biobehavioral Reviews·Marilyn D Skinner, Henri-Jean Aubin
Apr 7, 2009·Sleep Medicine Reviews·Andreas JaehneMagdolna Hornyak
May 19, 2007·Pharmacology, Biochemistry, and Behavior·T K BookerAllan C Collins
Dec 23, 2003·Journal of Internal Medicine·B RoduK Asplund
Dec 13, 2006·Addiction·Saul ShiffmanMark Balabanis
Dec 21, 2004·Biological Psychiatry·Leslie K JacobsenKenneth R Pugh
Nov 14, 2006·Addictive Behaviors·Harry PrapavessisJ Robert Grove

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.