Characterization of toxicokinetics and toxicodynamics with linear systems theory: application to lead-associated cognitive decline

Environmental Health Perspectives
J M LinksW F Stewart

Abstract

We present a theoretical approach to analysis of toxicokinetics and toxicodynamics using linear systems theory. In our approach, we define two impulse response functions that characterize the kinetic behavior of an environmental agent in the body and the dynamic time-course behavior of its effect on the body. This approach provides a formalism for understanding the relation among exposure, dose, and cumulative biologically effective dose and for understanding the implications of an effect time-course on cross-sectional and longitudinal data analyses. We use lead-associated cognitive decline as a specific example where the approach may be applied.

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Citations

Oct 24, 2006·Environmental Monitoring and Assessment·Ahmed Moustafa El NemrAzza Khaled
May 31, 2008·American Journal of Public Health·Keson TheppeangBrian S Schwartz
May 11, 2002·Environmental Health Perspectives·Walter F StewartAndrew C Todd
Jun 22, 2007·Occupational and Environmental Medicine·David KriebelNeil Pearce
Apr 2, 2010·Journal of Occupational and Environmental Medicine·Brian S SchwartzChristos Davatzikos
Feb 12, 2014·BioMed Research International·Lisa H MasonDong Y Han
Apr 25, 2012·Journal of Molecular Histology·Concepción Nava-RuizCamilo Ríos
Apr 6, 2016·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Y I Mahmoud, S S Sayed
Nov 4, 2008·Journal of Toxicology and Environmental Health. Part a·M A McDiarmidK S Squibb
Jul 26, 2008·Journal of Toxicology and Environmental Health. Part a·Ingvar A Bergdahl, Staffan Skerfving
Sep 30, 2009·Journal of Occupational and Environmental Medicine·Robert M ParkHarry A Roels
Dec 25, 2002·Epidemiology·Barbara S GlennBrian S Schwartz
May 31, 2013·The Journal of Toxicological Sciences·Keishi IshidaShigeru Ohta
Sep 22, 2012·American Journal of Industrial Medicine·Robert M Park, Weihong Chen
Feb 22, 2007·American Journal of Industrial Medicine·Walter F Stewart, Brian S Schwartz
Jul 17, 2019·Public Health Nursing·Jessica CastnerBarbara Polivka
Oct 1, 2020·Environmental Science and Pollution Research International·Supriya SharmaFaheem Hyder Pottoo

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