Characterization of trabecular bone plate-rod microarchitecture using multirow detector CT and the tensor scale: Algorithms, validation, and applications to pilot human studies

Medical Physics
Punam K SahaChadi A Calarge

Abstract

Osteoporosis is a common bone disease associated with increased risk of low-trauma fractures leading to substantial morbidity, mortality, and financial costs. Clinically, osteoporosis is defined by low bone mineral density (BMD); however, increasing evidence suggests that trabecular bone (TB) microarchitectural quality is an important determinant of bone strength and fracture risk. A tensor scale based algorithm for in vivo characterization of TB plate-rod microarchitecture at the distal tibia using multirow detector CT (MD-CT) imaging is presented and its performance and applications are examined. The tensor scale characterizes individual TB on the continuum between a perfect plate and a perfect rod and computes their orientation using optimal ellipsoidal representation of local structures. The accuracy of the method was evaluated using computer-generated phantom images at a resolution and signal-to-noise ratio achievable in vivo. The robustness of the method was examined in terms of stability across a wide range of voxel sizes, repeat scan reproducibility, and correlation between TB measures derived by imaging human ankle specimens under ex vivo and in vivo conditions. Finally, the application of the method was evaluated in p...Continue Reading

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Citations

Nov 11, 2016·Annals of Biomedical Engineering·Julio Carballido-GamioAndrew J Burghardt
Aug 16, 2017·IEEE Transactions on Visualization and Computer Graphics·Punam K SahaCheng Chen
Oct 4, 2017·Medical Physics·Rodrigo BaravalleTatijana Stošić
Feb 12, 2019·Medical Physics·Carlos A Peña-SolórzanoMatthew R Dimmock
Oct 25, 2017·Medical Physics·Cheng ChenPunam K Saha
Apr 10, 2020·Current Rheumatology Reports·Thomas M Link, Galateia Kazakia
Oct 22, 2020·Physics in Medicine and Biology·Indranil GuhaPunam Kumar Saha
Jun 12, 2021·Royal Society Open Science·A A FelderM Doube

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