PMID: 3295687Apr 1, 1987Paper

Characterization of Trypanosoma congolense serodemes in stocks isolated from cattle introduced onto a ranch in Kilifi, Kenya

Parasitology
R A MasakeK Nguli

Abstract

A herd of 20 cattle was introduced on a ranch in Kilifi, Coast Province of Kenya, where they were in contact with Glossina austeni for 6 months. In total, 65 trypanosome isolates were made from these animals. Examination of the isolates revealed that 61 were Trypanosoma congolense and 4 were T. theileri. Out of the 61 T. congolense isolates, 55 were successfully passaged and cloned in mice to provide trypanosome populations for further analyses. The stocks and their clones were inoculated into goats on which teneral G. morsitans centralis were later fed in order to provide metacyclics for use in serodeme analysis. Identification of serodemes was carried out by indirect immunofluorescence and neutralization using antimetacyclic hyperimmune sera prepared in mice against metacyclics of cloned trypanosome populations. So far 4 serodemes have been identified in 8 stocks and 7 clones. Each of the 9 stocks contained a mixture of at least 2 of the 4 serodemes identified. Furthermore, stocks isolated sequentially from individual animals contained the same serodemes despite repeated treatment with a curative dose (6 mg/kg body weight) of Berenil between isolations. From the latter finding, it can be inferred that the 4 serodemes were pre...Continue Reading

References

Jan 1, 1977·Advances in Experimental Medicine and Biology·J J Doyle
Dec 1, 1985·Annals of Tropical Medicine and Parasitology·G W Akol, M Murray
Dec 1, 1963·Experimental Parasitology·M P CUNNINGHAMW A WEBBER
Jun 1, 1986·Parasitology Today·V M Nantulya

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Citations

Sep 1, 1990·Veterinary Immunology and Immunopathology·V O TaiwoB O Ikede
May 1, 1990·Molecular and Biochemical Parasitology·P A Majiwa, L H Otieno
Apr 13, 2000·Veterinary Parasitology·D O KihuraniS M Mbiuki
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R F KooyJ P Overdulve
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·S GuptaK P Day
Jan 1, 1994·Parasitology Today·S Gupta, K P Day
Feb 1, 1991·Annals of Tropical Medicine and Parasitology·P DukesD G Godfrey
Dec 1, 1995·Annals of Tropical Medicine and Parasitology·K M BosompemV M Nantulya

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