PMID: 39435Mar 1, 1979

Characterization of two Chikungunya virus variants

Acta Virologica
A C ChanasD I Simpson

Abstract

The stability of virulence and plaque size of two variants of Chikungunya virus (genus Alphavirus) were examined. Mouse pathogenicity did not coincide with infective virus levels in the brain. An increase in the average survival times of mice receiving a lethal dose of the variant which allowed prolonged survival at high doses and harvested late after infection was observed. Studies in Vero cells suggested that the number of infective virus particles produced per cell was lower with the small plaque variant, though these cells were selective for this clone. On the other hand suckling mice or antisera favoured a more virulent large plaque variant.

Related Concepts

Anthropoidea
Brain
Chikungunya virus
Cytopathogenic Effect, Viral
Kidney
Variation (Genetics)
Viral Interference
Pathogenicity
Virus Replication

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