PMID: 1213985Oct 1, 1975Paper

Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU)

Journal of Biochemistry
K SugaharaI Yamashina

Abstract

Two major glycoasparagines (2-acetamido-N-(4'-L-aspartyl)-2-deoxy-beta-D-glycosylamines) were isolated from the urine of patients with aspartylglycosylaminuria (AGU). They were composed of equimolar amounts of sialic acid, galactose, glucosamine, and aspartic acid. They were isomeric with respect to the position of sialic acid attachment, since they produced the same glycoasparagine on incubation with the neuraminidase from Clostridium perfringens. The structure of the resulting sialic acid-free glycoasparagine was determined as beta-Gal-(1 leads to 4)-beta-GlcNAc-Asn based on the following findings. It produced galactose on incubation with beta-galactosidase, and N-acetyllactosamine and aspartic acid on incubation with 4-L-aspartylglycosylamine amindo hydrolase.

Citations

Nov 1, 1979·European Journal of Biochemistry·M RenlundS L Koskela
Jun 17, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Ikuo Yamashina
Jan 1, 1982·Journal of Inherited Metabolic Disease·C P Maury
Oct 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·K SugaharaI Y Yamashina

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