Characterization of Upper Gastrointestinal Symptoms, Gastric Motor Functions, and Associations in Patients with Diabetes at a Referral Center

The American Journal of Gastroenterology
Victor ChedidMichael Camilleri

Abstract

Our aim was to characterize upper gastrointestinal (UGI) symptoms and associations in individuals with diabetes mellitus (DM) who had undergone evaluation of gastric emptying (GE) and accommodation (GA) at a referral center. From the Mayo Clinic Rochester electronic medical records of adults with diabetes types 1 and 2 (DM1 and DM2) evaluated between January 1997 and December 2015, we extracted demographics, UGI symptoms, current medications, treatments for diabetes, GE solids by scintigraphy, GA by single photon emission computed tomography (SPECT), and diabetes complications. We compared subgroups with delayed (GE at 2 h <25% or GE at 4 h <75%), rapid (GE at 1 h > 35%), and normal GE, as well as reduced (<428 mL) and normal GA. We reviewed 108 patients (60.2% females, median age 49.0 years). Overall, 71.3% had DM2; one-third of these were insulin dependent and had fairly well-controlled diabetes (median HbA1c 6.7% (IQR 6.2; 7.9)). Manifestations of diabetic triopathy (peripheral neuropathy, nephropathy, and retinopathy) were uncommon at presentation with UGI symptoms. Nausea was the most common symptom (80.6%). There were single or combined GE (total 56%: rapid in 37%, slow in 19%) and GA (total 39%) abnormalities; there was ...Continue Reading

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Citations

Oct 29, 2019·The American Journal of Gastroenterology·Henry P ParkmanUNKNOWN NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Jan 22, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Saatchi KuwelkerAdil E Bharucha
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Mar 15, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Victor ChedidMichael Camilleri
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Feb 11, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael Camilleri
Feb 16, 2021·The Journal of Clinical Investigation·Michael Camilleri
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Nov 1, 2021·Gastroenterology·Michael Camilleri, Kenton M Sanders

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