Characterization of vascular histamine receptors in the rat

British Journal of Pharmacology
J R Powell, L B Shamel


1 In the rat the decrease in blood pressure caused by histamine involves activation of both H1- and H2-receptors. Since arterial pressure measurements alone do not permit the separation of responses into cardiac and vascular components, the following experiments were undertaken to study vascular histamine receptors. 2 Vascular responses were studied in the autoperfused hindquarters of anaesthetized rats. Intra-arterial histamine caused vasodilatation which was only partially attenuated by treatment with mepyramine, an H1-receptor antagonist. Treatment with metiamide, the H2-receptor antagonist, did not affect vasodilatation caused by histamine but did attenuate vasodilatation which persisted after mepyramine. 3 Intra-arterial 4-methylhistamine, an H2-receptor agonist, caused vasodilatation which was reduced by metiamide. The H1-receptor agonist, 2-(2-pyridyl)ethylamine also caused vasodilatation which was blocked by mepyramine. 4 It is concluded that in the rat, histamine causes vasodilatation mediated by both H1- and H2-receptors.


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Aug 1, 1974·Agents and Actions·R W BrimblecombeM E Parsons
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·A S Ash, H O Schild
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Apr 1, 1981·Agents and Actions·D A OwenE H Quinn
Jun 1, 1983·Pflügers Archiv : European journal of physiology·J Van de Voorde, I Leusen
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Related Concepts

Diastolic Blood Pressure
Antihistamines, Classical
Histamine H2 Antagonists
Histamine Receptor
Receptors, Histamine H1
Histamine H2 Receptors
Vascular Endothelium-Dependent Relaxation
Rats, Laboratory

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