Characterization of Visual Function, Interocular Variability and Progression Using Static Perimetry-Derived Metrics in RPGR-Associated Retinopathy.

Investigative Ophthalmology & Visual Science
James J L TeeMichel Michaelides

Abstract

To characterize bilateral visual function, interocular variability and progression by using static perimetry-derived volumetric and pointwise metrics in subjects with retinitis pigmentosa associated with mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. This was a prospective longitudinal observational study of 47 genetically confirmed subjects. Visual function was assessed with ETDRS and Pelli-Robson charts; and Octopus 900 static perimetry using a customized, radially oriented 185-point grid. Three-dimensional hill-of-vision topographic models were produced and interrogated with the Visual Field Modeling and Analysis software to obtain three volumetric metrics: VTotal, V30, and V5. These were analyzed together with Octopus mean sensitivity values. Interocular differences were assessed with the Bland-Altman method. Metric-specific exponential decline rates were calculated. Baseline symmetry was demonstrated by relative interocular difference values of 1% for VTotal and 8% with V30. Degree of symmetry varied between subjects and was quantified with the subject percentage interocular difference (SPID). SPID was 16% for VTotal and 17% for V30. Interocular symmetry in progression was greatest when quantified by V...Continue Reading

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Citations

Apr 30, 2020·Investigative Ophthalmology & Visual Science·Neruban KumaranMichel Michaelides
Sep 23, 2020·Investigative Ophthalmology & Visual Science·Michalis GeorgiouMichel Michaelides
Sep 22, 2020·Translational Vision Science & Technology·Neruban KumaranGary S Rubin
Jun 9, 2020·Asia-Pacific Journal of Ophthalmology·Mays Talib, Camiel J F Boon
Feb 6, 2020·International Journal of Molecular Sciences·Xuan-Thanh-An NguyenCamiel J F Boon
Dec 30, 2020·Investigative Ophthalmology & Visual Science·Valentina Di IorioFrancesca Simonelli
Mar 10, 2021·Clinical & Experimental Ophthalmology·Michalis GeorgiouMichel Michaelides
Aug 30, 2020·Progress in Retinal and Eye Research·Samantha R De SilvaOmar A Mahroo
May 25, 2020·American Journal of Ophthalmology·Jacque L DuncanUNKNOWN Foundation Fighting Blindness Consortium Investigator Group
Jul 22, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Theresa H BirtelMartin Gliem
Sep 30, 2021·International Ophthalmology Clinics·Michalis GeorgiouMichel Michaelides

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Methods Mentioned

BETA
GTPase

Clinical Trials Mentioned

NCT03116113
NCT03252847

Software Mentioned

XLSTAT
Excel
Octopus Eyesuite
Eyesuite
Visual Field Modeling and Analysis ( VFMA )
VFMA
GATE
SPID

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