Characterization of VP6 genes from rotavirus strains collected in the United States from 1996-2002

Virus Genes
Tara K KerinJ R Gentsch

Abstract

We sequenced 22 VP6 genes from common rotavirus strains P[8], G1; P[4], G2; P[8], G3; P[8], G4 and P[8], G9 and uncommon type P[6], G9 collected in the US over a 6-year period. All strains defined as members of VP6 antigenic subgroup (SG) I according to reactivity patterns with monoclonal antibodies formed a genetic cluster (Genogroup I) with SG I reference strains. Similarly, all strains in antigenic SGII formed a group (Genogroup II) with corresponding standard strains of the same SG. Most US strains of each genogroup had diverged by 10-15% from the VP6 gene sequence of reference strains collected >20 years earlier and some recent isolates from other countries. Evolutionary analysis demonstrated that recently isolated US strains of both genogroups have diverged into 2-3 related clusters consistent with other recent findings. Unexpectedly, some recent isolates from other countries have diverged greatly from both older reference isolates and from the recent US isolates characterized here. This finding suggests that genetic diversity in human rotavirus VP6 genes may be greater than previously recognized. These sequences will help in the construction of a VP6 gene database to aid in the development of broadly reactive molecular a...Continue Reading

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Citations

Jun 3, 2010·Archives of Virology·Safaa LamhoujebKirsten Mattison
Aug 1, 2008·Journal of Clinical Microbiology·Yi-Pei LinChun-Nan Lee
May 3, 2014·SpringerPlus·Martin M NyagaM Jeffrey Mphahlele
Jun 15, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vaishali S TatteShobha D Chitambar
May 13, 2015·Journal of Medical Virology·Adriana LuchsMaria do Carmo Sampaio Tavares Timenetsky
Sep 25, 2008·Journal of Medical Virology·Talissa de Moraes TavaresDivina das Dôres de Paula Cardoso
Mar 26, 2010·Journal of Medical Virology·Van Phan LeWonyong Kim
Nov 5, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Khuzwayo C JereMapaseka L Seheri
Dec 7, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S Mijatovic-RustempasicJ R Gentsch
Jun 19, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M D EsonaJ R Gentsch

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