Characterization of VP6 genes from rotavirus strains collected in the United States from 1996-2002

Virus Genes
Tara K KerinJ R Gentsch


We sequenced 22 VP6 genes from common rotavirus strains P[8], G1; P[4], G2; P[8], G3; P[8], G4 and P[8], G9 and uncommon type P[6], G9 collected in the US over a 6-year period. All strains defined as members of VP6 antigenic subgroup (SG) I according to reactivity patterns with monoclonal antibodies formed a genetic cluster (Genogroup I) with SG I reference strains. Similarly, all strains in antigenic SGII formed a group (Genogroup II) with corresponding standard strains of the same SG. Most US strains of each genogroup had diverged by 10-15% from the VP6 gene sequence of reference strains collected >20 years earlier and some recent isolates from other countries. Evolutionary analysis demonstrated that recently isolated US strains of both genogroups have diverged into 2-3 related clusters consistent with other recent findings. Unexpectedly, some recent isolates from other countries have diverged greatly from both older reference isolates and from the recent US isolates characterized here. This finding suggests that genetic diversity in human rotavirus VP6 genes may be greater than previously recognized. These sequences will help in the construction of a VP6 gene database to aid in the development of broadly reactive molecular a...Continue Reading


Jun 1, 1992·Journal of Clinical Microbiology·J R GentschM K Bhan
Mar 1, 1990·Journal of Clinical Microbiology·R BoomJ van der Noordaa
May 1, 1982·The Journal of General Virology·K TaniguchiT Urasawa
Aug 1, 1984·The British Journal of Venereal Diseases·R A CoutinhoJ van der Noordaa
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jul 1, 1994·Journal of Clinical Microbiology·B K DasR I Glass
Jan 1, 1994·Current Topics in Microbiology and Immunology·L J Saif, B Jiang
Mar 7, 2001·Journal of Clinical Microbiology·N A CunliffeC A Hart
Oct 19, 2002·Urology·Joel C HutchesonMichael C Carr
Feb 24, 2006·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
May 30, 2006·The Pediatric Infectious Disease Journal·Myrna D CharlesJoseph S Bresee

❮ Previous
Next ❯


Jun 3, 2010·Archives of Virology·Safaa LamhoujebKirsten Mattison
Aug 1, 2008·Journal of Clinical Microbiology·Yi-Pei LinChun-Nan Lee
May 3, 2014·SpringerPlus·Martin M NyagaM Jeffrey Mphahlele
Jun 15, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vaishali S TatteShobha D Chitambar
May 13, 2015·Journal of Medical Virology·Adriana LuchsMaria do Carmo Sampaio Tavares Timenetsky
Sep 25, 2008·Journal of Medical Virology·Talissa de Moraes TavaresDivina das Dôres de Paula Cardoso
Mar 26, 2010·Journal of Medical Virology·Van Phan LeWonyong Kim
Nov 5, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Khuzwayo C JereMapaseka L Seheri
Dec 7, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S Mijatovic-RustempasicJ R Gentsch
Jun 19, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M D EsonaJ R Gentsch

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.