Characterization of white matter changes along fibers by automated fiber quantification in the early stages of Alzheimer's disease

NeuroImage. Clinical
Xin ZhangAlzheimer's Disease Neuroimaging Initiative

Abstract

Brain white matter fiber bundles in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) have abnormalities not usually seen in unaffected subjects. Ideal algorithm of the localization-specific properties in white matter integrity might reveal the changes of tissue properties varying along each tract, while previous studies only detected the mean DTI parameters of each fiber. The aim of this study was to investigate whether these abnormalities of nerve fiber tracts are localized to specific regions of the tracts or spread throughout and to analyze which of the examined fiber tracts are involved in the early stages of Alzheimer's disease. In this study, we utilized VBA, TBSS as well as AFQ together to comprehensively investigate the white matter fiber impairment on 25 CE patients, 29 MCI patients and 34 normal control (NC) subjects. Two tract profiles, fractional anisotropy (FA) and mean diffusivity (MD), were extracted to evaluate the white matter integrity at 100 locations along each of 20 fiber tracts and then we validated the results with 27 CE patients, 21 MCI patients and 22 NC from the ADNI cohort. Also, we compare the AFQ with VBA and TBSS in our cohort. In comparison with NC, AD patients showed wid...Continue Reading

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Citations

Dec 5, 2019·Journal of Alzheimer's Disease : JAD·Emilie T ReasJames B Brewer
Jan 21, 2021·The British Journal of Ophthalmology·Yanming WangBensheng Qiu
Nov 19, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·H Diana RosasNicole Schupf
Apr 10, 2021·Scientific Reports·Kees M van HespenHugo J Kuijf
Apr 17, 2021·IBRO Neuroscience Reports·Ehsan ShekariMohammad Taghi Joghataei
Jun 10, 2021·Interdisciplinary Sciences, Computational Life Sciences·Xia-An BiZhaoxu Xing
Sep 23, 2021·Journal of Magnetic Resonance Imaging : JMRI·Huawei ZhangQiyong Gong

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Software Mentioned

AFQ
FSL
SPSS
VBA
CHippo
Genu
FLIRT
dtifit
PANDA
MATLAB

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