Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users

Addiction Biology
Taylor S WilliWilliam J Panenka

Abstract

With sufficient drug exposure, some individuals develop transient psychotic symptoms referred to as 'substance-induced psychosis' (SIP), which closely resemble the symptoms observed in schizophrenia spectrum disorders. The comparability in psychotic presentation between SIP and the schizophrenias suggests that similar underlying neural deficits may contribute to the emergence of psychosis across these disorders. Only a small number of studies have investigated structural alterations in SIP, and all have been limited to volumetric imaging methods, with none controlling for the effects of chronic drug exposure. To investigate white matter abnormalities associated with SIP, diffusion tensor imaging was employed in a group of individuals with cocaine-associated psychosis (CAP; n = 24) and a cocaine-dependent non-psychotic (CDN) group (n = 43). Tract-based spatial statistics was used to investigate group differences in white matter diffusion parameters. The CAP group showed significantly lower fractional anisotropy values than the CDN group (p < 0.05) in voxels within white matter tracts of fronto-temporal, fronto-thalamic and interhemispheric pathways. The greatest differences in white matter integrity were present in the corpus ca...Continue Reading

References

Jan 1, 1992·Schizophrenia Bulletin·M SatoT Hamamura
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jan 1, 1997·Cerebral Cortex·L JänckeH Steinmetz
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Sep 13, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yoshimoto SekineNorio Mori
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul M ThompsonEdythe D London
Nov 16, 2004·Annals of the New York Academy of Sciences·Hiroshi Ujike, Mitsumoto Sato
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Jul 27, 2005·Biological Psychiatry·Richard A A KanaanPhilip K McGuire
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Sep 14, 2006·Addiction·Rebecca McKetinLeanne Hides
May 9, 2007·Schizophrenia Bulletin·Andreas Konrad, Georg Winterer
Oct 2, 2007·Drug and Alcohol Dependence·Kelvin O LimJohn P Rotrosen
Jun 11, 2008·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Elizabeth JacobsIruma Bello
Jan 9, 2009·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Jul 6, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kathleen M GrantRick A Bevins
Jul 26, 2011·Schizophrenia Research·Lina OrikabeKiyoto Kasai
Jan 1, 2013·Drug and Alcohol Dependence·William J PanenkaAlasdair M Barr
Aug 10, 2013·The American Journal of Psychiatry·Fidel Vila-RodriguezWilliam G Honer
Aug 8, 2014·Frontiers in Human Neuroscience·Jennifer H HsiehFleur M Howells

❮ Previous
Next ❯

Citations

May 29, 2018·Psychological Medicine·Patrick DomenUNKNOWN for Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)
Feb 13, 2017·Psychopharmacology·Peter D AlexanderAlasdair M Barr
Apr 20, 2018·Frontiers in Neuroscience·Jessica W Y YuenAlasdair M Barr
Feb 2, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·M SabeS Kaiser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here