DOI: 10.1101/495564Dec 13, 2018Paper

Characterization of young and old adult brains: An EEG functional connectivity analysis

BioRxiv : the Preprint Server for Biology
Bahar MoezziMitchell R Goldsworthy


Brain connectivity studies have reported that functional networks change with older age. We aim to (1) investigate whether electroencephalography (EEG) data can be used to distinguish between individual functional networks of young and old adults; and (2) identify the functional connections that contribute to this classification. Two eyes-open resting-state EEG recording sessions with 64 electrodes for each of 22 younger adults (19-37 years) and 22 older adults (63-85 years) were conducted. For each session, imaginary coherence matrices in theta, alpha, beta and gamma bands were computed. A range of machine learning classification methods were utilized to distinguish younger and older adult brains. A support vector machine (SVM) classifier was 94% accurate in classifying the brains by age group. We report decreased functional connectivity with older age in theta, alpha and gamma bands, and increased connectivity with older age in beta band. Most connections involving frontal, temporal, and parietal electrodes, and approximately two-thirds of connections involving occipital electrodes, showed decreased connectivity with older age. Just over half of the connections involving central electrodes showed increased connectivity with o...Continue Reading

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