Characterization, prediction and evolution of plant peroxisomal targeting signals type 1 (PTS1s)

Biochimica Et Biophysica Acta
Sigrun ReumannThomas Lingner

Abstract

Our knowledge of the proteome of plant peroxisomes and their functional plasticity is far from being complete, primarily due to major technical challenges in experimental proteome research of the fragile cell organelle. Several unexpected novel plant peroxisome functions, for instance in biotin and phylloquinone biosynthesis, have been uncovered recently. Nevertheless, very few regulatory and membrane proteins of plant peroxisomes have been identified and functionally described up to now. To define the matrix proteome of plant peroxisomes, computational methods have emerged as important powerful tools. Novel prediction approaches of high sensitivity and specificity have been developed for peroxisome targeting signals type 1 (PTS1) and have been validated by in vivo subcellular targeting analyses and thermodynamic binding studies with the cytosolic receptor, PEX5. Accordingly, the algorithms allow the correct prediction of many novel peroxisome-targeted proteins from plant genome sequences and the discovery of additional organelle functions. In this review, we provide an overview of methodologies, capabilities and accuracies of available prediction algorithms for PTS1 carrying proteins. We also summarize and discuss recent quant...Continue Reading

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Citations

Feb 7, 2016·Biochimica Et Biophysica Acta·Ralf Erdmann
Jun 8, 2018·Journal of Integrative Plant Biology·Ronghui PanJianping Hu
Sep 12, 2018·Bioscience Reports·Véronique Larosa, Claire Remacle
Jul 26, 2017·The Plant Journal : for Cell and Molecular Biology·Kim L GonzalezBonnie Bartel
Jan 5, 2019·Journal of Integrative Plant Biology·Francisco J CorpasJosé M Palma
Oct 24, 2019·Journal of Experimental Botany·Hannes LansingAntje Von Schaewen
Apr 17, 2020·The New Phytologist·Elizabeth R Waters, Elizabeth Vierling
Feb 23, 2019·Journal of Integrative Plant Biology·Christian FalterSigrun Reumann
Aug 22, 2018·Nature Plants·Laura K HenryNatalia Dudareva
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Dmitry KechasovSigrun Reumann
Nov 22, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Markus Kunze
Mar 7, 2021·International Journal of Molecular Sciences·Francisco J CorpasJosé M Palma

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