Characterization, quantification, and localization of passenger T lymphocytes and NK cells in human liver before transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
F R PruvotJ P Dessaint

Abstract

Quantification and localization of the main lymphocyte populations were studied in the livers of normal (n = 8) and brain dead (n = 8) subjects. Cytometric analysis performed on mononuclear cell suspensions obtained from liver biopsies was compared to an automatic image analysis of immunostained sections. The overall number of liver associated lymphocytes was in the usual range of peripheral blood content (2 to 9x10(9) cells). Phenotypic analysis showed predominant NK and CD8+ cells that highly expressed class II antigen and CD25 and CD69 activation markers. Quantitative mapping of these activated lymphocytes revealed their preferential localization in the portal tract and the perisinusoidal area as compared to the pericentrolobular zone, especially in donor livers. This strategic localization could suggest a possible early cooperation between donor lymphocytes and initial infiltrating cells from the recipient and could explain the special immunological status of allografted livers.

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Citations

Oct 1, 1996·Immunology and Cell Biology·H S Warren
Jun 29, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Viviana MorosoJaap Kwekkeboom
Sep 24, 2004·Transplant Immunology·Jacques Pirenne, Masaru Kawai
Nov 30, 2006·Immunology Letters·Katrin S Blum, Reinhard Pabst
Mar 29, 2000·Journal of Hepatology·J R JonssonE E Powell
Mar 4, 2018·Cancer Immunology, Immunotherapy : CII·Aglaia DomouchtsidouMonika Lindemann
Jan 4, 2003·Nature Reviews. Immunology·Ian Nicholas Crispe
Feb 2, 2019·Nutrition Research Reviews·Sabrina CampisanoAndrea N Chisari
Jan 11, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mohamed A MorsyRobert W Vaughan
Apr 12, 2016·Cellular & Molecular Immunology·Mark W RobinsonCliona O'Farrelly
Sep 16, 2006·Immunological Reviews·Ian N CrispeSherry Wuensch

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