Characterizations of resting-state modulatory interactions in the human brain

Journal of Neurophysiology
Xin Di, Bharat B Biswal

Abstract

Functional connectivity between two brain regions, measured using functional MRI (fMRI), has been shown to be modulated by other regions even in a resting state, i.e., without performing specific tasks. We aimed to characterize large-scale modulatory interactions by performing region-of-interest (ROI)-based physiophysiological interaction analysis on resting-state fMRI data. Modulatory interactions were calculated for every possible combination of three ROIs among 160 ROIs sampling the whole brain. Firstly, among all of the significant modulatory interactions, there were considerably more negative than positive effects; i.e., in more cases, an increase of activity in one region was associated with decreased functional connectivity between two other regions. Next, modulatory interactions were categorized as to whether the three ROIs were from one single network module, two modules, or three different modules (defined by a modularity analysis on their functional connectivity). Positive modulatory interactions were more represented than expected in cases in which the three ROIs were from a single module, suggesting an increase within module processing efficiency through positive modulatory interactions. In contrast, negative modul...Continue Reading

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Citations

Feb 1, 2019·Human Brain Mapping·Maddalena BocciaCecilia Guariglia
Jun 23, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Hui Juan ChenFeng Chen
Jul 18, 2017·Frontiers in Aging Neuroscience·Yuanyuan ChenDong Ming
Sep 18, 2020·Brain Structure & Function·Pedro Henrique Rodrigues da SilvaRenata F Leoni
Sep 27, 2019·Frontiers in Psychology·Filippo Cieri, Roberto Esposito
May 2, 2020·Brain Structure & Function·Hang YangBharat Biswal
Nov 2, 2020·Magnetic Resonance Imaging·Anna Rita EgbertUNKNOWN Harmonia Group
Jun 22, 2021·Brain and Behavior·Joelle AmirRajeet Singh Saluja

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