Characterizing differences in mortality at the low end of the fitness spectrum in individuals with cardiovascular disease.

European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Sandra MandicVictor F Froelicher

Abstract

A graded but nonlinear relationship exists between fitness and mortality, with the greatest mortality differences occurring between the least-fit (first, Q1) and the next-least-fit (second, Q2) quintiles of fitness. The purpose of this study was to compare clinical characteristics, exercise test responses, and physical activity (PA) patterns in Q1 versus Q2 in patients with cardiovascular disease (CVD). Observational retrospective study. A total of 5101 patients with a history of CVD underwent clinical treadmill testing and were followed up for 9.1+/-5.5 years. Patients were classified into quintiles of exercise capacity measured in metabolic equivalents. Clinical characteristics, treadmill test results, and recreational PA patterns were compared between Q1 (n = 923) and Q2 (n = 929). Q1 had a nearly two-fold increase in age-adjusted relative risk of cardiovascular mortality compared with Q2 (hazard ratio: 3.79 vs. 2.04, P<0.05; reference: fittest quintile). Q1 patients were older, had more extensive use of medications, and were more likely to have a history of typical angina (35 vs. 28%), myocardial infarction (30 vs. 24%), chronic heart failure (25 vs. 14%), claudication (15 vs. 9%) and stroke (9 vs. 6%) compared with Q2 (all...Continue Reading

References

May 1, 1991·Journal of the American College of Cardiology·J MyersV F Froelicher
Mar 6, 1986·The New England Journal of Medicine·R S PaffenbargerC C Hsieh
Mar 15, 1994·The American Journal of Cardiology·J MyersV F Froelicher
Feb 25, 1993·The New England Journal of Medicine·L SandvikK Rodahl
Jul 1, 1993·Journal of the American College of Cardiology·C K MorrisA Hideg
Mar 27, 2001·Archives of Internal Medicine·J A LaukkanenJ T Salonen
Apr 27, 2001·Medicine and Science in Sports and Exercise·P T Williams
Mar 15, 2002·The New England Journal of Medicine·Jonathan MyersJ Edwin Atwood
Jan 5, 2005·The American Journal of Medicine·Jonathan MyersVictor Froelicher
Mar 24, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Jonathan Myers
Dec 2, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Ross ArenaMary Ann Peberdy
Apr 21, 2007·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Jonathan MyersVictor F Froelicher
Jan 24, 2008·Circulation·Peter KokkinosSteven Singh
Jul 2, 2009·Medicine and Science in Sports and Exercise·Sandra MandicVictor F Froelicher

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Citations

Jan 5, 2011·Biological Research for Nursing·Kimberly R WarrenDeanna L Kelly
May 3, 2016·Journal of Sports Sciences·Sara KnaepsJohan Lefevre
May 2, 2014·European Journal of Preventive Cardiology·Frank BeutnerStephan Gielen
Apr 9, 2013·Emergency Medicine Australasia : EMA·Natalie Tan, David McDonald Taylor
Apr 23, 2013·Disability and Rehabilitation·Sandra MandicMichael J A Williams
May 9, 2014·British Journal of Sports Medicine·Wendy J BrownAdrian E Bauman
Feb 13, 2013·European Journal of Clinical Investigation·Stefanie L De BuyserStefan Goemaere

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