PMID: 9523441Apr 2, 1998Paper

Characterizing dose-response: I: Critical assessment of the benchmark dose concept

Risk Analysis : an Official Publication of the Society for Risk Analysis
J A MurrellR W Morris

Abstract

We present a critical assessment of the benchmark dose (BMD) method introduced by Crump as an alternative method for setting a characteristic dose level for toxicant risk assessment. The no-observed-adverse-effect-level (NOAEL) method has been criticized because it does not use all of the data and because the characteristic dose level obtained depends on the dose levels and the statistical precision (sample sizes) of the study design. Defining the BMD in terms of a confidence bound on a point estimate results in a characteristic dose that also varies with the statistical precision and still depends on the study dose levels. Indiscriminate choice of benchmark response level may result in a BMD that reflects little about the dose-response behavior available from using all of the data. Another concern is that the definition of the BMD for the quantal response case is different for the continuous response case. Specifically, defining the BMD for continuous data using a ratio of increased effect divided by the background response results in an arbitrary dependence on the natural background for the endpoint being studied, making comparison among endpoints less meaningful and standards more arbitrary. We define a modified benchmark do...Continue Reading

References

Oct 1, 1984·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·K S Crump
Aug 1, 1995·Regulatory Toxicology and Pharmacology : RTP·R L KodellD W Gaylor
Jul 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R J KavlockC A Kimmel
Apr 1, 1995·Regulatory Toxicology and Pharmacology : RTP·M Haag-GrönlundK Victorin
Apr 1, 1995·Regulatory Toxicology and Pharmacology : RTP·D G BarnesH L Spitzer
May 26, 1995·European Journal of Pharmacology·A P Van BirgelenA Brouwer
May 1, 1995·Toxicology and Applied Pharmacology·A P Van BirgelenM Van den Berg
Aug 1, 1994·Regulatory Toxicology and Pharmacology : RTP·P A MalschB L Finley
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·E M FaustmanC A Kimmel
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B C AllenE M Faustman
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B C AllenE M Faustman
Nov 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T R NarasimhanS Safe
Apr 1, 1994·Regulatory Toxicology and Pharmacology : RTP·T R Auton
Mar 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J L LarsonB E Butterworth
Dec 1, 1995·Regulatory Toxicology and Pharmacology : RTP·F J Murray
Dec 1, 1995·Regulatory Toxicology and Pharmacology : RTP·J A Gastel, T R Sutter

❮ Previous
Next ❯

Citations

Oct 30, 2001·Chemosphere·P IsnardE Vindimian
May 31, 2001·Environmental Toxicology and Pharmacology·S DekkersM A.J. Rennen
Jul 27, 2000·Food Additives and Contaminants·C Portier
Jul 8, 2009·Critical Reviews in Food Science and Nutrition·Ulf HammerlingNils-Gunnar Ilbäck
Feb 17, 2000·Annals of the New York Academy of Sciences·R L Kodell, D W Gaylor
Aug 5, 2011·Environmental Health Perspectives·Salomon SandDaniel Krewski
Jun 20, 2002·Critical Reviews in Toxicology·Kenny Crump
Nov 5, 2003·Critical Reviews in Toxicology·Agneta Falk FilipssonKatarina Victorin
Jul 3, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·Matteo GoldoniAntonio Mutti
Sep 5, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kristi KuljusKatarina Victorin
Jun 27, 2012·Journal of Applied Toxicology : JAT·Salomon SandMattias Öberg
Sep 7, 2005·Regulatory Toxicology and Pharmacology : RTP·Kim Z TravisZoe K Welsh
Feb 3, 1999·Regulatory Toxicology and Pharmacology : RTP·H A BartonB C Allen
Mar 22, 2001·Regulatory Toxicology and Pharmacology : RTP·L A GephartM Pelekis
Mar 10, 2000·Journal of Biopharmaceutical Statistics·L A Hothorn, D Hauschke
Jun 14, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Salomon SandNils-Gunnar Ilbäck
Jul 8, 2016·Environmental Health Perspectives·Salomon SandDaniel Krewski
Sep 20, 2007·Journal of Applied Toxicology : JAT·Salomon SandAgneta Falk Filipsson
Dec 3, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Salomon SandAgneta Falk Filipsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved