Characterizing dynamic interactions between ultradian glucocorticoid rhythmicity and acute stress using the phase response curve.

PloS One
James RankinJohn R Terry

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis is a dynamic oscillatory hormone signalling system that regulates the pulsatile secretion of glucocorticoids from the adrenal glands. In addition to regulation of basal levels of glucocorticoids, the HPA axis provides a rapid hormonal response to stress that is vitally important for homeostasis. Recently it has become clear that glucocorticoid pulses encode an important biological signal that regulates receptor signalling both in the central nervous system and in peripheral tissues. It is therefore important to understand how stressful stimuli disrupt the pulsatile dynamics of this system. Using a computational model that incorporates the crucial feed-forward and feedback components of the axis, we provide novel insight into experimental observations that the size of the stress-induced hormonal response is critically dependent on the timing of the stress. Further, we employ the theory of Phase Response Curves to show that an acute stressor acts as a phase-resetting mechanism for the ultradian rhythm of glucocorticoid secretion. Using our model, we demonstrate that the magnitude of an acute stress is a critical factor in determining whether the system resets via a Type 1 or Type 0 me...Continue Reading

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Citations

Nov 14, 2014·Journal of the Royal Society, Interface·J J WalkerJ R Terry
Sep 28, 2014·Expert Opinion on Drug Safety·Georgina M Russell, Stafford L Lightman
Jul 10, 2012·Brain, Behavior, and Immunity·Gordon Broderick
Mar 21, 2015·Nature Reviews. Neuroscience·Martin EgelandCarmine M Pariante
Jun 24, 2017·Bulletin of Mathematical Biology·Elisabeth O BangsgaardJohnny T Ottesen
Jul 10, 2019·The Journal of Nutrition·Thomas W TilstonTimothy Wells
Jul 21, 2015·PloS One·Travis J A CraddockGordon Broderick
Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·K KalafatakisS L Lightman
Nov 19, 2019·Molecular and Cellular Endocrinology·Caroline M B Focke, Karl J Iremonger
Feb 2, 2021·Frontiers in Behavioral Neuroscience·Julietta A ShengRobert J Handa
Jan 30, 2021·Computational and Structural Biotechnology Journal·Xiaoou ChengTom Chou
Jan 14, 2021·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ioannis P Androulakis
Aug 28, 2021·International Journal of Molecular Sciences·Francisco J Carrera AriasTravis J A Craddock
Dec 11, 2017·Best Practice & Research. Clinical Endocrinology & Metabolism·Femke S den Boon, R Angela Sarabdjitsingh

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