Characterizing heart failure in the ventricular volume domain

Clinical Medicine Insights. Cardiology
Peter L M Kerkhof

Abstract

Heart failure (HF) may be accompanied by considerable alterations of left ventricular (LV) volume, depending on the particular phenotype. Two major types of HF have been identified, although heterogeneity within each category may be considerable. All variants of HF show substantially elevated LV filling pressures, which tend to induce changes in LV size and shape. Yet, one type of HF is characterized by near-normal values for LV end-diastolic volume (EDV) and even a smaller end-systolic volume (ESV) than in matched groups of persons without cardiac disease. Furthermore, accumulating evidence indicates that, both in terms of shape and size, in men and women, the heart reacts differently to adaptive stimuli as well as to certain pharmacological interventions. Adjustments of ESV and EDV such as in HF patients are associated with (reverse) remodeling mechanisms. Therefore, it is logical to analyze HF subtypes in a graphical representation that relates ESV to EDV. Following this route, one may expect that the two major phenotypes of HF are identified as distinct entities localized in different areas of the LV volume domain. The precise coordinates of this position imply unique characteristics in terms of the actual operating point f...Continue Reading

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Citations

Feb 16, 2018·Advances in Physiology Education·Peter L M KerkhofNeal Handly
Dec 5, 2020·The Canadian Journal of Cardiology·Jacinthe BouletJean-Lucien Rouleau

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Methods Mentioned

BETA
transgenic
biopsies
coronary artery bypass
antisense oligonucleotides

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