Characterizing hypervascular and hypovascular metastases and normal bone marrow of the spine using dynamic contrast-enhanced MR imaging.

AJNR. American Journal of Neuroradiology
N R KhademA I Holodny

Abstract

The role of DCE-MR imaging in the study of bone marrow perfusion is only partially developed, though potential applications for routine use in the clinical setting are beginning to be described. We hypothesize that DCE-MR imaging can be used to discriminate between hypervascular and hypovascular metastases based on measured perfusion variables. We conducted a retrospective study of 26 patients using conventional MR imaging and DCE-MR imaging. Patients were assigned to a hypervascular or hypovascular group based on tumor pathology. ROIs were drawn around normal-appearing bone marrow (internal controls) and enhancing tumor areas. Average wash-in enhancement slope, average peak enhancement signal percentage change, and average peak enhancement signal percentage change in areas of highest wash-in enhancement slope were calculated. Indices were compared among control, hypervascular, and hypovascular groups. Conventional imaging was assessed by calculating pre- to postgadolinium signal percentage changes in hypervascular and hypovascular lesions. Hypervascular and hypovascular tumors differed significantly with regard to wash-in enhancement slope (P < .01; hypervascular 95% CI, 22.5-26.5 AU/s; hypovascular 95% CI, 14.1-20.9 AU/s) and...Continue Reading

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Citations

Apr 10, 2015·Journal of Magnetic Resonance Imaging : JMRI·Dong XingHui Lin
Aug 4, 2015·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Brian C JungKyung K Peck
Feb 7, 2015·Journal of Magnetic Resonance Imaging : JMRI·Julio Arevalo-PerezSasan Karimi
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Nov 23, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jiahui ZhangNing Lang
Jul 28, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Xiao-Xi MengWei-Hua Dong
Nov 20, 2016·Journal of Magnetic Resonance Imaging : JMRI·Jun Seung BaikYoHan Sohn
Sep 28, 2013·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Sreejit NairAthos Patsalides
Aug 21, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Giancarlo FacchiniGiuseppe Rossi

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