Characterizing intercellular signaling peptides in drug addiction.

Neuropharmacology
Elena V RomanovaJonathan V Sweedler

Abstract

Intercellular signaling peptides (SPs) coordinate the activity of cells and influence organism behavior. SPs, a chemically and structurally diverse group of compounds responsible for transferring information between neurons, are broadly involved in neural plasticity, learning and memory, as well as in drug addiction phenomena. Historically, SP discovery and characterization has tracked advances in measurement capabilities. Today, a suite of analytical technologies is available to investigate individual SPs, as well as entire intercellular signaling complements, in samples ranging from individual cells to entire organisms. Immunochemistry and in situ hybridization are commonly used for following preselected SPs. Discovery-type investigations targeting the transcriptome and proteome are accomplished using high-throughput characterization technologies such as microarrays and mass spectrometry. By integrating directed approaches with discovery approaches, multiplatform studies fill critical gaps in our knowledge of drug-induced alterations in intercellular signaling. Throughout the past 35 years, the National Institute on Drug Abuse has made significant resources available to scientists that study the mechanisms of drug addiction. ...Continue Reading

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R SimantovS H Snyder
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A GoldsteinL Hood
Apr 1, 1977·Neuropharmacology·H Y YangE Costa
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R Simantov, S H Snyder
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y YangE Costa
Jan 16, 1984·Brain Research·P W GlimcherB G Hoebel
Aug 5, 1993·Nature·S P FodorC L Adams
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J HenzelC Watanabe
Mar 21, 1998·Science·D T ChiuJ A Lundqvist
Jun 4, 1998·Journal of Neuroimmunology·P K PetersonC C Chao
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·L ThimJ T Clausen
Apr 29, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·X GanM Fiala
Oct 8, 1999·Psychosomatic Medicine·G Torres, J M Horowitz
Jan 20, 2000·Journal of the National Cancer Institute·F R Balkwill
Feb 5, 2000·Nature Biotechnology·S S RubakhinJ V Sweedler
Feb 5, 2000·Analytical Chemistry·Z ZhangN J Dovichi
Mar 31, 2000·Trends in Biotechnology·L LiJ V Sweedler
Dec 8, 2000·Advanced Drug Delivery Reviews·M I DaviesS M Lunte
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
May 1, 2001·Molecular Neurobiology·A R Gintzler, S Chakrabarti
May 31, 2001·Genome Research·R S Hewes, P H Taghert
Jun 8, 2001·Reviews in the Neurosciences·R C Pierce, A A Bari
Jun 20, 2001·Journal of Neurochemistry·L LiJ V Sweedler
Aug 30, 2001·Molecular Psychiatry·S AkbarianR Jaenisch
Jun 14, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Eric JüttlerMarkus Schwaninger
Oct 5, 2002·Science·Michael A RiehleMark R Brown
Jan 1, 2003·Brain Research Bulletin·K Steven LaForgeMary Jeanne Kreek
Apr 29, 2003·Journal of Proteome Research·Marcus SvenssonPer E Andren
Jun 13, 2003·Life Sciences·J N JaworskiM J Kuhar

❮ Previous
Next ❯

Citations

Jun 12, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elena V RomanovaJonathan V Sweedler
Aug 7, 2012·Journal of Neurochemistry·Elena V RomanovaJoshua M Gulley
Apr 12, 2014·Biochemical and Biophysical Research Communications·Nobutoshi OtaJonathan V Sweedler
Sep 18, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alfredo Ramos-MiguelJesús A García-Sevilla
Sep 25, 2021·Mass Spectrometry Reviews·Ashley PhetsanthadLingjun Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.