Characterizing ion mobility and collision cross section of fatty acids using electrospray ion mobility mass spectrometry

Journal of Mass Spectrometry : JMS
Fang ZhangYinlong Guo

Abstract

This study investigated the ion mobility (IM) and the collision cross section (CCS) of fatty acids (FAs) using electrospray IM MS. The IM analysis of 18 FA ions showed intriguing differences among the saturated FAs, monounsaturated FAs, multi-unsaturated FAs, and cis-isomer/trans-isomer with respect to the aliphatic tail chains. The length of aliphatic tail chain present in the ion structures had a strong influence on the differentiation of drift, while the number of double bond showed a weaker influence. The tiny drift differences between cis-isomer and trans-isomer were also observed. In the CCS measurements, two internal standards were involved in the mobility calibration and accuracy estimation. It insured our empirical CCS values were of high experimental precision (±0.35% or better) and accuracy (±0.25% or better). Moreover, the mass-to-charge ratio (m/z) - mobility plots obtained by ion mobility spectrometry with mass spectrometry analysis of FAs - was used to investigate the structural relationship between the molecules. Each series of FAs sharing a similar structure was aligned in the linear plot. Finally, the developed procedure was applied to the determination of FAs in rat adipose tissues, and it allowed the presenc...Continue Reading

References

Nov 2, 1993·Biochimica Et Biophysica Acta·L Wojtczak, P Schönfeld
Jul 3, 1998·Biochemical Society Transactions·J C BrownJ C Stanley
Apr 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M LecomteN Wiernsperger
Apr 1, 1954·The American Journal of Medicine·R J BINGM GILBERT
May 16, 2006·Biochimica Et Biophysica Acta·Marco Di Paola, Michele Lorusso
Sep 28, 2007·Journal of Oleo Science·Seiichi ShirasawaChiemi Satoh
Jan 18, 2008·Journal of Mass Spectrometry : JMS·Abu B KanuHerbert H Hill
Jul 8, 2008·Archives of Biochemistry and Biophysics·Angel SandovalPaul N Black
Sep 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Cyrous O KanganiJames P Delany
Apr 17, 2012·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Guo-Liang LiJin-Mao You
Dec 22, 2012·Analytical Chemistry·Pierluigi DelmonteJeanne I Rader
Apr 23, 2013·Journal of Analytical Methods in Chemistry·Lidong CaoQiliang Huang
Jul 23, 2013·Journal of Pharmaceutical and Biomedical Analysis·Jiapeng LengYinlong Guo
Mar 20, 2014·Analytical Chemistry·Giuseppe PagliaGiuseppe Astarita

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Citations

May 2, 2016·Current Opinion in Biotechnology·Jody Christopher MayJohn Allen McLean
Mar 17, 2017·Nature Protocols·Giuseppe Paglia, Giuseppe Astarita
Apr 7, 2017·Analytical Chemistry·Adam HollerbachR Graham Cooks
Jan 4, 2018·Chemistry : a European Journal·Nicolas LespesJean-François Brière
May 4, 2018·Rapid Communications in Mass Spectrometry : RCM·Zhenzhen XuShuming Yang
Mar 1, 2019·Nature Communications·Katrina L LeaptrotJohn A McLean
Jun 11, 2016·Biochemical Society Transactions·James R JohnsonAnthony J W Hall
Sep 13, 2019·Journal of Lipid Research·Sarah E HancockTodd W Mitchell
Jan 9, 2019·Analytical and Bioanalytical Chemistry·Monika CechováPetr Bednář
Dec 4, 2016·Journal of the American Society for Mass Spectrometry·Christopher D ChouinardRichard A Yost
Apr 25, 2018·Journal of the American Society for Mass Spectrometry·James P Di GiovanniRobert C Murphy
Dec 31, 2016·Analytical Chemistry·Jody C MayJohn A McLean

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