Characterizing pinprick-evoked brain potentials before and after experimentally induced secondary hyperalgesia

Journal of Neurophysiology
Emanuel N van den BroekeThomas Klein

Abstract

Secondary hyperalgesia is believed to be a key feature of "central sensitization" and is characterized by enhanced pain to mechanical nociceptive stimuli. The aim of the present study was to characterize, using EEG, the effects of pinprick stimulation intensity on the magnitude of pinprick-elicited brain potentials [event-related potentials (ERPs)] before and after secondary hyperalgesia induced by intradermal capsaicin in humans. Pinprick-elicited ERPs and pinprick-evoked pain ratings were recorded in 19 healthy volunteers, with mechanical pinprick stimuli of varying intensities (0.25-mm probe applied with a force extending between 16 and 512 mN). The recordings were performed before (T0) and 30 min after (T1) intradermal capsaicin injection. The contralateral noninjected arm served as control. ERPs elicited by stimulation of untreated skin were characterized by 1) an early-latency negative-positive complex peaking between 120 and 250 ms after stimulus onset (N120-P240) and maximal at the vertex and 2) a long-lasting positive wave peaking 400-600 ms after stimulus onset and maximal more posterior (P500), which was correlated to perceived pinprick pain. After capsaicin injection, pinprick stimuli were perceived as more intense ...Continue Reading

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Citations

Jul 12, 2016·NeuroImage·Sylvie NozaradanAlexandre Lehmann
Apr 7, 2017·Journal of Neurophysiology·Sylvie NozaradanMarion Cousineau
Feb 21, 2019·Journal of Neurophysiology·E N van den BroekeA Mouraux
Apr 15, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Lisa GoudmanMargot De Kooning
Aug 15, 2020·European Journal of Pain : EJP·Paulina S ScheurenMichèle Hubli
Dec 15, 2016·Frontiers in Physiology·Matthew D JonesBenjamin K Barry
Jun 20, 2019·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Jan RosnerMichèle Hubli
Sep 15, 2020·Pain·Wacław M AdamczykKerstin Luedtke
Mar 25, 2021·European Journal of Pain : EJP·Charles QuesadaLuis Garcia-Larrea
Jun 30, 2021·Brain Topography·Razieh AlemiAlexandre Lehmann

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