Characterizing sarcoma dominance pattern in uterine carcinosarcoma: Homologous versus heterologous element

Surgical Oncology
Koji MatsuoLynda D Roman

Abstract

To examine significance of sarcoma dominance (SD) patterns in uterine carcinosarcoma (UCS). This is a secondary analysis of multicenter retrospective study examining women with stages I-IV UCS who underwent primary surgery. SD was defined as >50% of sarcoma component in uterine tumor. SD patterns were grouped as homologous sarcoma without SD (homo/non-dominance, n = 351), heterologous sarcoma without SD (hetero/non-dominance, n = 174), homologous sarcoma with SD (homo/dominance, n = 175), and heterologous sarcoma with SD (hetero/dominance, n = 189), and correlated to tumor characteristics and survival. SD patterns were significantly associated with age, body habitus, carcinoma type, tumor size, depth of myometrial invasion, and nodal metastasis (all, P < 0.05). On univariate analysis, SD was associated with decreased progression-free survival (PFS) and cause-specific survival (CSS) in homologous cases (both, P < 0.05) but not in heterologous cases. On multivariate models, both homologous and heterologous SD patterns remained independent prognostic factors for decreased PFS (adjusted-hazard ratio [HR] ranges: homo/dominance 1.35-1.69, and hetero/dominance 1.47-1.64) and CSS (adjusted-HR ranges: 1.52-1.84 and 1.66-1.81, respectiv...Continue Reading

Citations

Aug 15, 2018·Annals of Surgical Oncology·Koji MatsuoLynda D Roman
Jul 22, 2019·Cancers·Susanna LeskelaJosé Palacios
May 30, 2021·Critical Reviews in Oncology/hematology·Gaetano PezzicoliStella D'Oronzo

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