PMID: 9541542Apr 29, 1998Paper

Characterizing sequence variation in the VP1 capsid proteins of foot and mouth disease virus (serotype 0) with respect to virion structure

Journal of Molecular Evolution
D HaydonM E Woolhouse

Abstract

The VP1 capsid protein of foot and mouth disease virus (FMDV) is highly polymorphic and contains several of the major immunogenic sites important to effective antibody neutralization and subsequent viral clearance by the immune system. Whether this high level of polymorphism is of adaptive value to the virus remains unknown. In this study we examined sequence data from a set of 55 isolates in order to establish the nature of selective pressures acting on this gene. Using the known molecular structure of VP1, the rates and ratios of different types of nonsynonymous and synonymous changes were compared between different parts of the protein. All parts of the protein are subject to purifying selection, but this is greatest amongst those amino acid residues within beta-strands and is significantly reduced at residues exposed on the capsid surface, which include those residues demonstrated by previous mutational analyses to permit the virus to escape from monoclonal antibody binding. The ratios of nonsynonymous substitution resulting in various forms of physicochemically radical and conserved amino acid change were shown to be largely equal throughout these different parts of the protein. There was a consistently higher level of non...Continue Reading

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Citations

Sep 1, 2001·Preventive Veterinary Medicine·D T HaydonN J Knowles
Aug 23, 2002·Microbes and Infection·Soren AlexandersenAlex I Donaldson
Apr 16, 2004·Clinical Microbiology Reviews·Marvin J Grubman, Barry Baxt
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Oct 27, 2010·Drug Discovery Today·Kan X WuJustin J H Chu
Sep 11, 2012·Journal of Virological Methods·Yan LiAiqiang Xu
Nov 30, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mehar AngezSyed Sohail Zahoor Zaidi
Mar 14, 2014·Clinical and Vaccine Immunology : CVI·Tesfaalem TekleghiorghisAldo Dekker
Jul 13, 2020·Journal of Fish Biology·E E Becerril-GarcíaP Salinas-De León
Feb 19, 2017·Archives of Virology·Taotao YangXinglong Yu
Apr 10, 2020·Frontiers in Veterinary Science·Lauro Velazquez-SalinasElizabeth Rieder

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