Characterizing Structural Changes With Devolving Remyelination Following Experimental Demyelination Using High Angular Resolution Diffusion MRI and Texture Analysis

Journal of Magnetic Resonance Imaging : JMRI
Tim LuoYunyan Zhang

Abstract

Changes in myelin integrity are associated with the pathophysiology of many neurological diseases, including multiple sclerosis. However, noninvasive measurement of myelin injury and repair remains challenging. Advanced MRI techniques including diffusion tensor imaging (DTI), neurite orientation dispersion and density index (NODDI), and texture analysis have shown promise in quantifying subtle abnormalities in white matter structure. To determine whether and how these advanced imaging methods help understand remyelination changes after demyelination using a mouse model. Prospective, longitudinal. Demyelination was induced in the thoracic spinal cord of 21 mice using the chemical toxin lysolecithin. 9.4T ASSESSMENT: Imaging was done at day 7 (demyelination) and days 14 to 35 (ongoing remyelination) postsurgery, followed by histology. Image analysis focused on both lesions and peri-lesional areas where remyelination began. In histology, we quantified the complexity of tissue alignment using angular entropy, in addition to staining area. Two-way analysis of variance was performed for assessing differences between tissue types and across timepoints, followed by post-hoc analysis to correct for multiple comparisons (P < 0.05). All d...Continue Reading

References

Jun 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A MacKayD Graeb
Oct 1, 1995·Journal of Neurocytology·N D Jeffery, W F Blakemore
Jul 11, 2003·Medical Physics·H ZhuJ R Mitchell
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Jan 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shu-Wei SunSheng-Kwei Song
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew L AlexanderAaron S Field
Nov 11, 2010·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·C P LoizouC S Pattichis
Dec 7, 2011·International Journal of Biomedical Imaging·Yunyan Zhang
Oct 5, 2012·Annals of Neurology·Lorraine W LauV Wee Yong
Jan 1, 2013·Brain Sciences·Maria PodbielskaEdward L Hogan
Apr 14, 2015·Journal of Visualized Experiments : JoVE·Michael B KeoughV Wee Yong
Jul 4, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·D StefanovićD Lalošević
Dec 24, 2015·Frontiers in Neurology·Danielle E HarlowAugusto A Miravalle
Jan 13, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Yunyan ZhangJeroen Jg Geurts
Jul 6, 2017·Functional Neurology·Torben SchneiderClaudia Gandini Wheeler-Kingshott
Nov 17, 2017·Nature Reviews. Neuroscience·Robin J M Franklin, Charles Ffrench-Constant

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Citations

Nov 7, 2020·AJNR. American Journal of Neuroradiology·S SaccoUNKNOWN University of California, San Francisco MS-EPIC Team
Aug 20, 2020·Journal of Neuroscience Methods·Kouhei KamiyaShigeki Aoki

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