Characterizing swallowing abnormalities in progressive supranuclear palsy

Neurology
I LitvanB C Sonies

Abstract

The dysphagia that occurs as an early sign of progressive supranuclear palsy (PSP), and which may predispose patients to aspiration pneumonia, has never been fully characterized. We evaluated 27 patients (mean +/- SEM: age, 64.9 +/- 1 years; symptom duration, 52 +/- 5 months) who met the clinical National Institute of Neurological Disorders and Stroke and Society for PSP (NINDS-SPSP) criteria for possible or probable PSP, with a swallowing questionnaire, an oral motor and speech examination, and either a modified barium swallow or ultrasound studies. Twenty-eight age- and sex-matched healthy controls (age, 65.6 +/- 1.5 years) were also evaluated with the questionnaire, oral examination, and the ultrasound study. We used ANOVA statistics to evaluate differences between groups; nonparametric correlations to assess associations between swallowing and motor and cognitive abnormalities; and logistic regression analysis to determine if the items of the questionnaire or oral examination predicted ultrasound or modified barium swallow abnormalities. While PSP patients had at least one complaint on the swallowing questionnaire (mean, 6.6), healthy controls had fewer and less relevant complaints (0.3). Patients with moderate-to-severe co...Continue Reading

Citations

Jul 12, 2002·Head & Neck·Barbara Roa PauloskiLinda Stachowiak
Apr 19, 2006·Journal of Neurology·L Ramio-TorrentiaD Genis
Mar 30, 2006·Current Treatment Options in Neurology·Irene van Balken, Irene Litvan
Nov 10, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Julia GatesGary D Gramigna
Sep 26, 2014·Tijdschrift voor gerontologie en geriatrie·J G Kalf, S de Wit
Nov 2, 2014·Journal of Movement Disorders·Cumhur Ertekin
Jan 27, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johannes A LangendijkBen J Slotman
Oct 13, 2015·Parkinsonism & Related Disorders·M GrunhoI Litvan
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Tobias WarneckeRainer Dziewas
Aug 5, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Cumhur Ertekin
Dec 19, 2006·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Kerry L Bladon, Eleanor Ross
Mar 13, 2008·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Ruiying Ding, Jeri A Logemann
Jan 7, 1999·Journal of Geriatric Psychiatry and Neurology·I Litvan, M Hutton
Aug 15, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Dai PuKaren M K Chan
Apr 19, 2019·Internal Medicine·George Umemoto, Hirokazu Furuya
Sep 27, 2019·Journal of Movement Disorders·Miseon Kwon, Jae-Hong Lee
Nov 5, 2019·Dysphagia·Heather M ClarkKeith A Josephs
Sep 21, 2018·Current Neurology and Neuroscience Reports·Karoline Knudsen, Per Borghammer
Oct 27, 2018·Movement Disorders Clinical Practice·Inga ClausTobias Warnecke
Jan 18, 2016·Movement Disorders Clinical Practice·Walter MaetzlerBenjamin Bender
Jun 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·James C BordersMichelle S Troche
Jul 6, 2021·Frontiers in Neurology·Emma ViscidiGünter U Höglinger
Jul 28, 2021·Dysphagia·Enrico AlfonsiGiuseppe Cosentino
Nov 14, 2018·Dementia and Geriatric Cognitive Disorders·Courtney LewisAdam P Vogel

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