Characterizing synaptic conductance fluctuations in cortical neurons and their influence on spike generation

Journal of Neuroscience Methods
Zuzanna PiwkowskaAlain Destexhe

Abstract

Cortical neurons are subject to sustained and irregular synaptic activity which causes important fluctuations of the membrane potential (V(m)). We review here different methods to characterize this activity and its impact on spike generation. The simplified, fluctuating point-conductance model of synaptic activity provides the starting point of a variety of methods for the analysis of intracellular V(m) recordings. In this model, the synaptic excitatory and inhibitory conductances are described by Gaussian-distributed stochastic variables, or "colored conductance noise". The matching of experimentally recorded V(m) distributions to an invertible theoretical expression derived from the model allows the extraction of parameters characterizing the synaptic conductance distributions. This analysis can be complemented by the matching of experimental V(m) power spectral densities (PSDs) to a theoretical template, even though the unexpected scaling properties of experimental PSDs limit the precision of this latter approach. Building on this stochastic characterization of synaptic activity, we also propose methods to qualitatively and quantitatively evaluate spike-triggered averages of synaptic time-courses preceding spikes. This analy...Continue Reading

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Citations

Apr 12, 2011·Journal of Computational Neuroscience·Patrick JahnSusanne Ditlevsen
Nov 13, 2008·Cognitive Neurodynamics·Romain Brette
Jan 1, 2011·Journal of Mathematical Neuroscience·Jiaoyan WangJonathan E Rubin
Sep 26, 2009·PLoS Computational Biology·Sami El BoustaniYves Frégnac
Jul 16, 2010·PLoS Computational Biology·Jonathan Platkiewicz, Romain Brette
May 17, 2011·PLoS Computational Biology·Jonathan Platkiewicz, Romain Brette
Mar 19, 2014·Neural Networks : the Official Journal of the International Neural Network Society·Jiaoyan WangGuanrong Chen
Jun 9, 2009·Journal of Physiology, Paris·Martin PospischilAlain Destexhe
May 5, 2009·Neuron·Bilal Haider, David A McCormick
Nov 26, 2008·Neuroscience·M PospischilA Destexhe
Jul 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Songting LiDavid Cai
Sep 13, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Arnaud Tonnelier
Feb 6, 2020·Frontiers in Neural Circuits·Scott RichTaufik A Valiante

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