Characterizing the inhibitory action of zinc oxide nanoparticles on allergic-type mast cell activation

Molecular Immunology
Bryce N FeltisA L Lopata

Abstract

The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we evaluated the effect of size and dispersion state of ZnO and TiO2 NPs, compared to "bulk" ZnO, on mast cell degranulation and viability. ZnO and TiO2 NPs were characterized using dynamic light scattering and disc centrifugation. Rat basophilic leukaemia (RBL-2H3) cells and primary mouse bone marrow-derived mast cells (BMMCs) were exposed to ZnO and TiO2 NPs of different sizes (25-200 nm) and surface coatings at concentrations from 1 to 200 μg/mL. The effect of NPs on immunoglobulin E (IgE)-dependent mast cell degranulation was assessed by measuring release of both β-hexosaminidase and histamine via colorimetric and ELISA assays. The intracellular level of Zn(2+) and Ca(2+) ions were measured using zinquin ethyl ester and Fluo-4 AM fluorescence probes, respectively. Cellular viability was determined using the soluble tetrazolium-based MTS colorimetric assay. Exposure of RBL-2H3 and primary mouse BMMC to ZnO NPs marke...Continue Reading

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Citations

Nov 22, 2017·Particle and Fibre Toxicology·Kirsty MeldrumMartin O Leonard
Apr 8, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brett A DuguayMarianna Kulka
Sep 27, 2019·Current Pharmaceutical Design·Romina MitarotondaMauricio C De Marzi
Nov 10, 2020·Tissue Engineering. Part B, Reviews·Emily W OzpinarDonald O Freytes

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