Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri , a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus

MSphere
Matthew E MeadAntonis Rokas

Abstract

Aspergillus fischeri is closely related to Aspergillus fumigatus, the major cause of invasive mold infections. Even though A. fischeri is commonly found in diverse environments, including hospitals, it rarely causes invasive disease. Why A. fischeri causes less human disease than A. fumigatus is unclear. A comparison of A. fischeri and A. fumigatus for pathogenic, genomic, and secondary metabolic traits revealed multiple differences in pathogenesis-related phenotypes. We observed that A. fischeri NRRL 181 is less virulent than A. fumigatus strain CEA10 in multiple animal models of disease, grows slower in low-oxygen environments, and is more sensitive to oxidative stress. Strikingly, the observed differences for some traits are of the same order of magnitude as those previously reported between A. fumigatus strains. In contrast, similar to what has previously been reported, the two species exhibit high genomic similarity; ∼90% of the A. fumigatus proteome is conserved in A. fischeri, including 48/49 genes known to be involved in A. fumigatus virulence. However, only 10/33 A. fumigatus biosynthetic gene clusters (BGCs) likely involved in secondary metabolite production are conserved in A. fischeri and only 13/48 A. fischeri BGCs...Continue Reading

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Citations

Dec 14, 2019·Microbiology Resource Announcements·Shu ZhaoJohn G Gibbons
Feb 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bruno PerlattiGerald Bills
Dec 12, 2019·Journal of Natural Products·Sonja L KnowlesNicholas H Oberlies
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Mar 5, 2021·Journal of Natural Products·Tamam El-ElimatNicholas H Oberlies
Jun 19, 2021·Fungal Biology·M C Tamayo-OrdóñezY J Tamayo-Ordóñez

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Datasets Mentioned

BETA
GMS
AF293

Methods Mentioned

BETA
NMR
gene knockout
PCR
X-ray

Software Mentioned

Circos
NUCMER
Easyfig
antiSMASH
eulerAPE

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