Characterizing the severe asthma population in the United States: claims-based analysis of three treatment cohorts in the year prior to treatment escalation

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Patrick W SullivanJ Michael Woolley

Abstract

Little is known about the disposition of severe patients prior to treatment escalation. To classify patients by treatment step using pharmacy data and describe their economic and healthcare utilization, insurance status, and sociodemographic characteristics in the year prior to escalation to Global Initiative for Asthma (GINA) steps 4 and 5. This was a retrospective claims cohort study of asthma patients (age 12-75 years) newly initiated on "stable therapy" (three consecutive months of therapy) with omalizumab, high intensity corticosteroids (HICS; ≥1000 µg/d inhaled fluticasone equivalent or oral prednisone), or high-dose inhaled corticosteroid (HDICS; ≥500-<1000 µg/d fluticasone equivalent) from 2002 to 2011. Other asthma treatments were compared as a reference. Of 25,297 patients, 856 initiated omalizumab, 6926 initiated HICS, and 11,445 initiated HDICS. In the year prior to treatment escalation to omalizumab, HICS, and HDICS, respectively, individuals had high annual mean medical expenditures ($14,071, $12,030, and $7570), utilization (27 outpatient and 10 specialty care visits; 19 outpatient and three specialty; 15 outpatient and two specialty), asthma-related prescription drugs (11.74, 7.8, and 5.17) and chronic comorbidi...Continue Reading

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Citations

Sep 15, 2016·Current Medical Research and Opinion·Patrick LefebvreAnand A Dalal
May 1, 2017·The Journal of Allergy and Clinical Immunology·Patrick W SullivanMichael Schatz
May 1, 2019·NPJ Primary Care Respiratory Medicine·Hiromasa InoueEmil Loefroth
Jul 11, 2019·BMC Pulmonary Medicine·Hugo NeffenClaudia Soares
Jul 18, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jennifer TrevorChristopher S Ambrose
Nov 7, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael S BlaissMichael B Foggs

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