Abstract
Little is known about the disposition of severe patients prior to treatment escalation. To classify patients by treatment step using pharmacy data and describe their economic and healthcare utilization, insurance status, and sociodemographic characteristics in the year prior to escalation to Global Initiative for Asthma (GINA) steps 4 and 5. This was a retrospective claims cohort study of asthma patients (age 12-75 years) newly initiated on "stable therapy" (three consecutive months of therapy) with omalizumab, high intensity corticosteroids (HICS; ≥1000 µg/d inhaled fluticasone equivalent or oral prednisone), or high-dose inhaled corticosteroid (HDICS; ≥500-<1000 µg/d fluticasone equivalent) from 2002 to 2011. Other asthma treatments were compared as a reference. Of 25,297 patients, 856 initiated omalizumab, 6926 initiated HICS, and 11,445 initiated HDICS. In the year prior to treatment escalation to omalizumab, HICS, and HDICS, respectively, individuals had high annual mean medical expenditures ($14,071, $12,030, and $7570), utilization (27 outpatient and 10 specialty care visits; 19 outpatient and three specialty; 15 outpatient and two specialty), asthma-related prescription drugs (11.74, 7.8, and 5.17) and chronic comorbidi...Continue Reading
References
Jan 1, 1996·Archives of Family Medicine·D A StempelL L Sturm
Jul 17, 2004·American Journal of Respiratory and Critical Care Medicine·Eric D BatemanUNKNOWN GOAL Investigators Group
Feb 1, 2005·Allergy·J BousquetG Della Cioppa
Jun 15, 2006·BMC Pulmonary Medicine·Martyn R PartridgeWilliam W Busse
May 8, 2007·The Journal of Allergy and Clinical Immunology·Stephen P PetersScott T Weiss
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Mar 7, 2009·The New England Journal of Medicine·Christopher H Fanta
May 21, 2009·BMC Pulmonary Medicine·Katayoun BahadoriJ Mark FitzGerald
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Patrick W SullivanShao-Lee Lin
Mar 23, 2011·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Patrick W SullivanVahram Ghushchyan
Nov 19, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Michael S BroderAshley Yegin
Jun 26, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Marie-Hélène LafeuillePatrick Lefebvre
Jul 3, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Patrick W SullivanGary Globe
Nov 26, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Junho JangSean D Sullivan
Citations
Sep 15, 2016·Current Medical Research and Opinion·Patrick LefebvreAnand A Dalal
May 1, 2017·The Journal of Allergy and Clinical Immunology·Patrick W SullivanMichael Schatz
Jul 27, 2018·Current Medical Research and Opinion·Stephanie ChenXiao Xu
May 1, 2019·NPJ Primary Care Respiratory Medicine·Hiromasa InoueEmil Loefroth
Jul 11, 2019·BMC Pulmonary Medicine·Hugo NeffenClaudia Soares
Sep 14, 2019·The European Respiratory Journal·Hyun LeeSang-Heon Kim
Jan 8, 2021·Allergy·Hyun LeeHo Joo Yoon
Jul 18, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jennifer TrevorChristopher S Ambrose
Nov 7, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michael S BlaissMichael B Foggs