Characterizing the Surface Roughness Length Scales of Lactose Carrier Particles in Dry Powder Inhalers

Molecular Pharmaceutics
Bernice Mei Jin TanPaul W S Heng

Abstract

Surface roughness is well recognized as a critical physical property of particulate systems, particularly in relation to adhesion, friction, and flow. An example is the surface property of carrier particles in carrier-based dry powder inhaler (DPI) formulations. The numerical characterization of roughness remains rather unsatisfactory due to the lack of spatial (or length scale) information about surface features when a common amplitude parameter such as average roughness ( Ra) is used. An analysis of the roughness of lactose carrier particles at three different length scales, designed for specificity to the study of interactive mixtures in DPI, was explored in this study. Three Ra parameters were used to represent the microscale, intermediate scale, and macroscale roughness of six types of surface-modified carriers. Coating of micronized lactose fines on coarse carrier particles increased their microroughness from 389 to 639 nm while the macroroughness was not affected. Roller compaction at higher roll forces led to very effective surface roughening, particularly at longer length scales. Changes in Ra parameters corroborated the visual observations of particles under the scanning electron microscope. Roughness at the intermedi...Continue Reading

References

Nov 30, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·B H J DickhoffH W Frijlink
May 27, 2009·Drug Development and Industrial Pharmacy·Antesar M Boshhiha, Nora A Urbanetz
Feb 22, 2012·International Journal of Pharmaceutics·Kyrre ThalbergMagnus Fransson
May 19, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E M LittringerN A Urbanetz
Aug 18, 2012·Biochimica Et Biophysica Acta·Palma D AntonioVito Capozzi
Aug 21, 2015·Current Pharmaceutical Design·Yu-Wei LinQi Tony Zhou
Apr 20, 2016·Pharmaceutical Research·Bernice Mei Jin TanPaul Wan Sia Heng

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