Characterizing white matter alterations subject to clinical laterality in drug-naïve de novo Parkinson's disease.

Human Brain Mapping
Yiming XiaoAli R Khan

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and nonmotor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatment strategies. Microstructural imaging techniques, including diffusion tensor imaging (DTI), allows inspection of white matter integrity to study the pathogenesis of various neurological conditions. Previous voxel-based analyses with DTI measures, such as fractional anisotropy and mean diffusivity have uncovered changes in brain regions that are associated with PD, but the conclusions were inconsistent, partially due to small patient cohorts and the lack of consideration for clinical laterality onset, particularly in early PD. Fixel-based analysis (FBA) is a recent framework that offers tract-specific insights regarding white matter health, but very few FBA studies on PD exist. We present a study that reveals strengthened and weakened white matter integrity that is subject to symptom laterality in a large drug-naïve de novo PD cohort using complementary DTI and FBA measures. The f...Continue Reading

References

Dec 18, 2001·Human Brain Mapping·Thomas E Nichols, Andrew P Holmes
Sep 28, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Siamak Ardekani, Usha Sinha
Dec 23, 2009·Journal of Magnetic Resonance Imaging : JMRI·José V ManjónMontserrat Robles
Apr 10, 2010·IEEE Transactions on Medical Imaging·Nicholas J TustisonJames C Gee
Sep 29, 2011·NeuroImage·Simon F EskildsenUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 4, 2012·Parkinsonism & Related Disorders·Renato P MunhozIrene Litvan
Oct 9, 2012·Brain : a Journal of Neurology·Christoph ScherflerWerner Poewe
Dec 15, 2012·NeuroImage·Robert E SmithAlan Connelly
Feb 14, 2013·Brain : a Journal of Neurology·Tao Wu, Mark Hallett
Oct 10, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Christian R BaumannDaniel Waldvogel
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Aug 16, 2016·NeuroImage·Jelle VeraartEls Fieremans
Aug 3, 2017·NeuroImage. Clinical·Cyril Atkinson-ClementOlivier Coulon
Aug 11, 2017·NeuroImage. Clinical·Martin CousineauMaxime Descoteaux
Jan 9, 2018·Brain : a Journal of Neurology·Remika MitoAlan Connelly
Jan 20, 2018·Neurorehabilitation and Neural Repair·Ming-Ching WenLouis C S Tan
Nov 11, 2018·Human Brain Mapping·Gong-Jun JiKai Wang
Oct 28, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Laura PelizzariFrancesca Baglio
Apr 17, 2020·Stroke; a Journal of Cerebral Circulation·Natalia EgorovaAmy Brodtmann

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