Charge-conversional poly(amino acid)s derivatives as a drug delivery carrier in response to the tumor environment

Journal of Biomedical Materials Research. Part a
Se Rim YoonJong-Duk Kim

Abstract

A charge-converting and pH-dependent nanocarrier was achieved by conjugating 2,3-dimethylmaleic anhydride (DMMA) to the amino group of an octadecyl grafted poly (2-hydroxyethyl aspartamide) (PHEA-g-C(18)-NH(2)) backbone, thereby forming a spherical micelle. PHEA, a poly(amino acid)s derivative, was derived from poly(succinimide), which is biocompatible and biodegradable. DMMA, a detachable component at the tumor site, was added, preventing aggregation with negative blood serum and enhancing the nanocarrier's cellular uptake. The polymeric micelle was comprehensively characterized and doxorubicin was encapsulated successively. The cellular uptake and anticancer therapeutic effect were evaluated by flow cytometry, confocal laser scanning microscopy, and a MTT assay. The properties of the nanocarrier can further be exploited to develop an early detection module for cancer. The present work is also expected to advance the study of designing smart carriers for drug and gene delivery.

References

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Jul 11, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seung Rim YangJong-Duk Kim
Oct 25, 2007·Journal of Biomedical Materials Research. Part a·Seung Rim YangJong-Duk Kim
Jun 20, 2008·Journal of Biomedical Materials Research. Part a·Kwangwon SeoDukjoon Kim
Jul 26, 2008·Nature Nanotechnology·Dan PeerRobert Langer
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Apr 1, 2011·Chemical Communications : Chem Comm·Hee-Man YangJong-Duk Kim

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