Mar 24, 2020

Charge neutral rhenium tricarbonyl complexes of tridentate N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease

Dalton Transactions : an International Journal of Inorganic Chemistry
Nuchareenat WiratprukPeter J Barnard

Abstract

Two tridentate ligand systems bearing N-heterocyclic carbene (NHC), amine and carboxylate donor groups coupled to benzothiazole- or stilbene-based amyloid binding moieties were synthesised. Reaction of the imidazolium salt containing pro-ligands with Re(CO)5Cl yielded the corresponding rhenium metal complexes which were characterised by NMR, and X-ray crystallography. These ligands are of interest for the potential preparation of technetium-99m imaging agents for Alzheimer's disease and the capacity of these rhenium complexes bind to amyloid fibrils composed of amyloid-β peptide and amyloid plaques in human frontal cortex brain tissue was evaluated using fluorescence microscopy. These studies show that the complexes bound efficiently to amyloid-β fibrils and some evidence of binding to amyloid-β plaques.

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Mentioned in this Paper

Binding (Molecular Function)
Amyloid Fibrils
Technetium 99m
Pt-NHC complex
Fibril - Cell Component
Plaque (Lesion)
Amyloid beta-Peptides
Rhenium compound
Imidazolium chloride
Frontal Lobe

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