Charge-switchable nanocapsules with multistage pH-responsive behaviours for enhanced tumour-targeted chemo/photodynamic therapy guided by NIR/MR imaging

Nanoscale
Jia ZhouYingsheng Cheng

Abstract

Multifunctional nanoplatforms have been developed into advanced drug delivery systems for cancer therapy. In this study, we report a charge-switchable nanocapsule with multistage pH-responsive behaviors. First, DOX-encapsulated and oleylamine-embedded hollow structures with a diameter of 132 ± 21 nm are prepared via the double emulsion method. Subsequently, the hollow structures are encompassed by Gd-DTPA-, chlorin e6 (Ce6)-, and folate (FA)-modified BSA to form tumour-targeted, dual NIR/MR imaging-guided and chemo-photodynamic therapeutic nanoplatforms. Importantly, the nanocapsule can intelligently switch its surface charge to positive under mildly acidic conditions (pH 6.5) with no release of Ce6 and DOX, which is confirmed by ξ-potential and cumulative release measurements. Moreover, confocal imaging pictures demonstrate that acid-sensitive DOX sealed in nanocapsules is progressively released into the nuclei of MGC-803 cells. These advantages as well as FA-targeting facilitate effective endocytosis and synergistic therapeutic efficacy. Selective tumour accumulation and long tumour retention time are further indicated by NIR/MR in vivo imaging. In addition, excellent therapeutic efficacy combined with chemotherapy (DOX) and ...Continue Reading

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Citations

Mar 12, 2019·Advanced Healthcare Materials·Qingxin MuMiqin Zhang
Jun 14, 2019·Contrast Media & Molecular Imaging·Juan PellicoJason J Davis
Sep 14, 2019·Journal of Biomedical Materials Research. Part a·Yanli BaoLi Chen
Jun 15, 2019·Advanced Healthcare Materials·Tianliang LiDaxiang Cui
Dec 6, 2018·Pharmaceuticals·Tuanwei Li, Lifeng Yan
Apr 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shuxin JiaJintao Yuan
Jun 27, 2019·Biomacromolecules·Roberto ZagamiAntonino Mazzaglia

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Methods Mentioned

BETA
imaging technique
fluorescence imaging
confocal microscopy
flow cytometry
dynamic light scattering

Software Mentioned

IR Flash
SPSS

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