Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity

Biomacromolecules
Todd Hoare, Robert Pelton

Abstract

Amphoteric, poly(N-isopropylacrylamide)-based microgels are functionalized with aminophenylboronic acid (PBA) functional groups to produce colloidally stable, glucose-responsive gel nanoparticles that exhibit glucose-dependent swelling responses at physiological temperature, pH, and ionic strength. Up to 2-fold volumetric swelling responses are observed in response to physiological glucose concentrations, the first such physiological response reported for a colloidally stable microgel. Amphoteric microgels can also be designed to both swell and deswell in response to glucose according to the pH of the medium, the concentration of PBA groups grafted to the microgel, and the relative concentrations of the cationic and anionic functional groups in the platform microgel. The increasing anionic charge density on the microgels observed at higher glucose binding fractions can be applied to switch the net charge of the microgels from cationic to anionic as the glucose concentration increases. Preliminary experiments suggest that such amphoteric PBA-microgels have a high capacity for insulin uptake and can selectively release more insulin at higher glucose concentrations under physiological conditions via glucose-induced, "on-off" switc...Continue Reading

References

Nov 1, 1985·Journal of Biomedical Materials Research·J KostM Singh
May 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·S SenelA Tuncel
Aug 16, 2003·Analytical Chemistry·Vladimir L AlexeevSanford A Asher
Feb 5, 2004·Journal of the American Chemical Society·Chad E ReeseSanford A Asher
Nov 14, 2006·Biomacromolecules·Yongjun ZhangShuiqin Zhou
Dec 13, 2006·Biomacromolecules·Véronique LapeyreValérie Ravaine

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Citations

Jul 17, 2013·Analytica Chimica Acta·Molla R IslamMichael J Serpe
Oct 21, 2009·Accounts of Chemical Research·Hans-Jörg Schneider, Robert M Strongin
Jun 5, 2013·Biomacromolecules·Ronja MånssonMartin Malmsten
Sep 10, 2011·Chemical Reviews·Qian WuZhefu Chen
Sep 7, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Christophe AnclaValérie Ravaine
Nov 8, 2011·Molecular Pharmaceutics·Kimberly Ann V ZubrisMark W Grinstaff
Aug 25, 2011·Chemical Communications : Chem Comm·Zesheng AnGuangyao Liu
Oct 15, 2013·Therapeutic Delivery·Akiko KiriyamaNobuhito Shibata
Apr 30, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·B V V S Pavan KumarM Eswaramoorthy
Dec 9, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·D M EckmannV R Muzykantov
Aug 14, 2012·The Journal of Physical Chemistry. B·Per HanssonMartin Malmsten
Oct 8, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Chaoyu ZhouHuayue Wu
Apr 27, 2010·Journal of Colloid and Interface Science·Christian JohanssonPer Hansson
Sep 11, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Valérie RavaineBogdan Catargi
Sep 24, 2008·Advances in Colloid and Interface Science·Brian R SaundersRobert Stepto
Jan 15, 2016·Journal of Biomaterials Science. Polymer Edition·Zhihua ChaiXuejun Ren
Jun 9, 2012·Small·Stéphane CuenotAlain M Jonas
May 14, 2011·Macromolecular Rapid Communications·Beilei WangLinqi Shi
Nov 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kruti S SoniTatiana K Bronich
May 3, 2016·Materials Science & Engineering. R, Reports : a Review Journal·Michael C KoettingNicholas A Peppas
Jun 10, 2016·Physical Chemistry Chemical Physics : PCCP·S A DenisovV Ravaine
Feb 6, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianhai Yang, Zhiqiang Cao
Jun 1, 2017·ACS Applied Materials & Interfaces·Dong YangRobert H Pelton
Nov 2, 2017·Scientific Reports·A AlibertiA Cusano
Sep 10, 2013·Chemical Communications : Chem Comm·Shuyan ZhouZunli Shen
Oct 24, 2017·Advanced Healthcare Materials·Ghorbanali Sharifzadeh, Hossein Hosseinkhani
Jun 21, 2018·Scientific Reports·M GiaquintoA Cusano
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chenyu WangLi Zhao
Nov 17, 2020·Biomaterials·Lisa R VolpattiDaniel G Anderson
Jan 28, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Gen LiPer M Claesson
Nov 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Zejun WangZhen Gu
May 13, 2010·The Journal of Physical Chemistry. B·Helena BysellMartin Malmsten

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