CHARGE syndrome: relations between behavioral characteristics and medical conditions

American Journal of Medical Genetics. Part a
M P J VervloedRonald J C Admiraal

Abstract

The behaviors and medical problems in 27 persons with CHARGE syndrome were studied, because it was hypothesized that their behavior might be partly dependent on the heterogeneous medical status. With the exception of more tics, cardiac surgery was associated with positive behaviors: less withdrawn behavior, better mood, and a more easy temperament. Tube feeding was also related to positive behavior, since participants with a history of tube feeding showed less intense behavior. Cerebral deficits were associated with three problem behaviors: more intense and withdrawn behavior and a worse mood. Deaf-blindness was associated with developmental delays in expressive and overall communication level, and recurrent middle ear infections correlated with delays in written language. Of all medical conditions, only the presence or absence of heart defects and cardiac surgery could differentiate between the participants with regard to the number of behavioral problems. Participants with heart surgery especially, had less behavior problems. The number of operations and hospitalizations was not associated with behavior, but the total length of the hospitalizations was. Long hospital stays were associated with less problem behavior, especiall...Continue Reading

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Citations

Aug 3, 2013·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Elisabeth LasserreVéronique Abadie
Jul 10, 2009·Journal of Developmental and Physical Disabilities·Josette WulffaertIna A van Berckelaer-Onnes
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Oct 31, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Kim D Blake, Alexandra S Hudson

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