Charged-Iron-Particles Found in Galactic Cosmic Rays are Potent Inducers of Epithelial Ovarian Tumors

Radiation Research
Birendra MishraUlrike Luderer

Abstract

Astronauts traveling in deep space are exposed to high-charge and energy (HZE) particles from galactic cosmic rays. We have previously determined that irradiation of adult female mice with iron HZE particles induces DNA double-strand breaks, oxidative damage and apoptosis in ovarian follicles, causing premature ovarian failure. These effects occur at lower doses than with conventional photon irradiation. Ovarian failure with resultant loss of negative feedback and elevated levels of gonadotropin hormones is thought to play a role in the pathophysiology of ovarian cancer. Therefore, we hypothesized that charged-iron-particle irradiation induces ovarian tumorigenesis in mice. In this study, three-month-old female mice were exposed to 0 cGy (sham) or 50 cGy iron ions and aged to 18 months. The 50 cGy irradiated mice had increased weight gain with age and lack of estrous cycling, consistent with ovarian failure. A total of 47% and 7% of mice irradiated with 50 cGy had unilateral and bilateral ovarian tumors, respectively, whereas 14% of mice in the 0 cGy group had unilateral tumors. The tumors contained multiple tubular structures, which were lined with cells positive for the epithelial marker cytokeratin, and had few proliferating...Continue Reading

References

May 1, 1986·Biology of Reproduction·B J Tennent, W G Beamer
Dec 1, 1995·Mutation Research·C C CapenK A Stitzel
Sep 15, 1998·Journal of Radiation Research·H WatanabeO Katoh
Oct 14, 1998·Oncology Reports·H WatanabeO Katoh
May 7, 2003·Cancer·Vivien W ChenCatherine N Correa
Nov 14, 2003·Reproductive Biology and Endocrinology : RB&E·Barbara C VanderhydenJean-François Ethier
Jan 22, 2005·Gynecologic Oncology·Allison W KurianAlice S Whittemore
May 2, 2006·The Lancet Oncology·Francis A Cucinotta, Marco Durante
Mar 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David C HodgsonLois B Travis
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiBarbara C Vanderhyden
May 15, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melissa J Romero-AleshireHeddwen L Brooks
Nov 17, 2009·American Journal of Epidemiology·Margaret A GatesShelley S Tworoger
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Mar 8, 2011·The American Journal of Surgical Pathology·Osama M Al-AghaC Blake Gilks
Feb 9, 2012·Journal of the National Cancer Institute·Lois B TravisJohn D Boice
Mar 8, 2012·Endocrinology·Lisa K Mullany, JoAnne S Richards
Oct 4, 2012·Health Physics·Helle Bielefeldt-OhmannMichael M Weil
Mar 8, 2013·Nature·Andrea Flesken-NikitinAlexander Yu Nikitin
Jul 7, 2014·Nature Cell Biology·Annie NgNick Barker
Nov 18, 2014·Journal of Women's Health·April E RoncaMarjorie Jenkins
Mar 10, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Hayato UrushimaKazuhisa Maeda
Mar 26, 2016·The American Journal of Pathology·Robert J Kurman, Ie-Ming Shih
Jun 3, 2016·Human Reproduction·Birendra MishraUlrike Luderer
Dec 21, 2016·Life Sciences in Space Research·Chiara La TessaAdam Rusek
May 22, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Birendra MishraUlrike Luderer
Oct 7, 2017·Mayo Clinic Proceedings·Ekta KapoorStephanie S Faubion

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Citations

Oct 16, 2019·Nature Reviews. Endocrinology·Birendra Mishra, Ulrike Luderer

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Methods Mentioned

BETA
lavage
light microscopy

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