PMID: 2506156Sep 1, 1989Paper

Charged particle radiotherapy for lesions encircling the brain stem or spinal cord

International Journal of Radiation Oncology, Biology, Physics
J R CastroM Decker

Abstract

Since 1981, a specialized technique has been under development at the University of California Lawrence Berkeley Laboratory for charged particle irradiation of tumors partially or completely encircling the brain stem or spinal cord. By dividing the target volume into two or more portions and using a combination of beams, a reasonably homogeneous irradiation of the target volume can be obtained which protects critical CNS structures from over-irradiation. This technique requires knowledge of the physical and biological effects of charged particles, precise, reproducible patient immobilization, careful treatment planning based upon Metrizamide contrast CT and/or MRI scanning, compensation for tissue inhomogeneities, and accurate, verifiable radiation delivery. Uncertainties in the dose distribution must be taken into account when prescribing treatment. We have used this technique in 47 patients with a variety of tumors abutting the brain stem and spinal cord, including chordoma, chondrosarcoma, meningioma, osteosarcoma and metastatic tumors. The results have shown a significant local control rate (62%) and the incidence of serious complications has been acceptable (13%). The median follow-up is 20 months with a range of 6-90 mont...Continue Reading

References

Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·G T ChenJ M Quivey
Apr 1, 1988·International Journal of Radiation Oncology, Biology, Physics·J R Castro, M M Reimers
Jan 1, 1986·Physics in Medicine and Biology·M UrieG T Chen
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·W M SaundersR E Walton
Oct 1, 1985·International Journal of Radiation Oncology, Biology, Physics·J R CastroS R Zink
Nov 1, 1983·Medical Physics·M Goitein, G T Chen

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Citations

Jan 1, 1995·Journal of Neuro-oncology·C M Faul, J C Flickinger
Mar 1, 1995·Radiation and Environmental Biophysics·J R Castro
Jan 1, 1992·Radiation and Environmental Biophysics·M Goitein
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·E B Hug, J E Munzenrider
Jul 15, 1996·International Journal of Radiation Oncology, Biology, Physics·P L Petti
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·J DebusM Wannenmacher
Jun 2, 1998·International Journal of Radiation Oncology, Biology, Physics·N MuthukumarJ C Flickinger
Aug 1, 1991·International Journal of Radiation Oncology, Biology, Physics·H Tatsuzaki, M M Urie
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·V UhlI Daftari
Jul 15, 1993·International Journal of Radiation Oncology, Biology, Physics·C A Perez
May 20, 1993·International Journal of Radiation Oncology, Biology, Physics·R SchoenthalerT L Phillips
Jul 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J R CastroT L Phillips
Mar 8, 2016·The Spine Journal : Official Journal of the North American Spine Society·Mitchell FosterKonstantina Karabatsou
Jun 23, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Eleanor A Blakely, Polly Y Chang
Jun 15, 2000·Clinical Oncology : a Journal of the Royal College of Radiologists·P T TaiJ Tonita
Jun 24, 2006·Neurosurgery Clinics of North America·Jonathan P S Knisely, Mark E Linskey

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