Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation

International Journal of Biological Macromolecules
Marita DionísioAna M Rosa da Costa

Abstract

Pullulan, a neutral polysaccharide, was chemically modified in order to obtain two charged derivatives: reaction with SO3(.)DMF complex afforded a sulfate derivative (SP), while reaction with glycidyltrimethylammonium chloride gave a quaternary ammonium salt (AP). The presence of the charged groups was confirmed by FTIR. Assessment of the positions where the reaction took place was based on (1)H- and (13)C NMR (COSY, HSQC-TOCSY, HSQC-DEPT, and HMBC) experiments. Estimation of the degree of substitution (DS) was made from elemental analysis data, and further confirmed by NMR peak areas in the case of AP. These new derivatives showed the capability to condense with each other, forming nanoparticles with the ability to associate a model protein (BSA) and displaying adequate size for drug delivery applications, therefore making them good candidates for the production of pullulan-based nanocarriers by polyelectrolyte complexation.

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Citations

Jan 4, 2017·International Journal of Biological Macromolecules·Luis BrazBruno Sarmento
Nov 28, 2016·International Journal of Biological Macromolecules·Xi ChenZhen-Ming Chi
Mar 12, 2021·Journal of Colloid and Interface Science·Giulia MugnainiMassimo Bonini
Jan 25, 2020·International Journal of Pharmaceutics·Fernanda C MoraesDidier Letourneur

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