Charged solvatochromic dyes as signal transducers in pH independent fluorescent and colorimetric ion selective nanosensors

Analytical Chemistry
Xiaojiang XieEric Bakker

Abstract

Ionophore-based ion selective optical nanosensors that operate independently of the sample pH are developed here by the use of electrically charged solvatochromic dyes as signal transducers. A series of dye molecules with a D-π-A structure was synthesized and characterized in various solvents and incorporated into ion selective nanospheres for K(+), Na(+), and H(+). Since dye leakage was greatly suppressed when the solvatochromic dyes were encapsulated in the nanosphere core, ion sensing nanospheres were explored for cellular ion imaging in Dictyostelium discoideum live cells but spontaneous dye loss resulted in undesired staining of cells. The in vitro analysis of potassium in human plasma was successfully demonstrated with this approach. A theoretical model was developed for the response of the ion selective nanosensors containing charged solvatochromic dyes. The nanosensors exhibited a tunable response range, high sensitivity, and good stability.

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Sep 12, 2013·Analytical Chemistry·Xiaojiang XieEric Bakker
Mar 4, 2014·Analytical Chemistry·Xiaojiang XieEric Bakker
Nov 12, 2014·Journal of the American Chemical Society·Xiaojiang XieEric Bakker
Jan 22, 2015·Analytical and Bioanalytical Chemistry·Xiaojiang Xie, Eric Bakker
Apr 30, 2015·Clinical Chemistry·Adie ViljoenAzad Ghuran

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Citations

Feb 29, 2016·Analytical and Bioanalytical Chemistry·Xiaojiang Xie
May 3, 2016·Analytical Chemistry·Katarzyna KłucinskaAgata Michalska
Feb 10, 2017·Journal of Molecular Modeling·Daniel Garcez S QuattrociocchiLeonardo Moreira da Costa
Mar 27, 2018·Chemistry : a European Journal·Lu WangEric Bakker
Jan 23, 2019·Chemical Communications : Chem Comm·Xinfeng DuXiaojiang Xie
Mar 30, 2019·The Analyst·Natalia ŁukasikAleksandra Małachowska
Nov 28, 2019·Analytical and Bioanalytical Chemistry·Hiroyuki ShibataDaniel Citterio
Mar 20, 2021·Analytica Chimica Acta·Yoshiki Soda, Eric Bakker
Feb 20, 2020·Talanta·Emilia StelmachAgata Michalska
Apr 25, 2019·Accounts of Chemical Research·Elena Zdrachek, Eric Bakker
Jun 30, 2019·Analytical Chemistry·Li DengXiaojiang Xie

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