Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes.

Proceedings of the National Academy of Sciences of the United States of America
M PriceC Deutsch

Abstract

We demonstrate that blockade of the lymphocyte voltage-gated K+ channel by charybdotoxin (CTX) inhibits lymphocyte mitogenesis. Charybdotoxin blocks conductance with a Ki of 0.3 nM and inhibits mitogen- and antigen-stimulated proliferation with a Ki of 0.5 nM. As opposed to the other blockers of the lymphocyte K+ channel, the inhibition of mitogenesis by CTX can be overcome selectively by exogenous recombinant interleukin 2 (IL-2); endogenous levels of IL-2 in the culture supernatants of stimulated cells are decreased by the presence of CTX. Our results suggest that the voltage-gated K+ channel is either directly or indirectly involved in IL-2 synthesis and/or secretion.

References

Mar 1, 1987·The Journal of General Physiology·T E DecourseyM D Cahalan
Jul 1, 1987·The Journal of General Physiology·A Hermann, C Erxleben
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Gimenez-GallegoM L Garcia
Mar 1, 1988·The Journal of General Physiology·R MacKinnon, C Miller
Jun 1, 1989·The Journal of General Physiology·S B SandsM D Cahalan
Jan 1, 1986·Annual Review of Immunology·W C Greene, W J Leonard
Aug 1, 1984·The Journal of Experimental Medicine·K G ChandyS Gupta
Jan 1, 1980·Biochimica Et Biophysica Acta·T J RinkR Y Tsien
Jan 1, 1984·Annual Review of Immunology·K A Smith
Dec 1, 1984·Journal of Cellular Physiology·E W GelfandS Grinstein

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Citations

Jul 1, 1992·Journal of Cellular Physiology·Y F WangS Cukierman
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·M L GarciaG J Kaczorowski
Sep 1, 1991·Journal of Clinical Immunology·B A Premack, P Gardner
Dec 20, 2005·The Journal of Membrane Biology·L A PardoW Stühmer
Jul 19, 2012·Purinergic Signalling·Sérgio José Macedo-JuniorAdair Roberto Soares Santos
Jan 1, 1993·Progress in Biophysics and Molecular Biology·J M Dubois, B Rouzaire-Dubois
Feb 1, 1996·Cellular Signalling·D J PhippsL C Schlichter
Jan 28, 2004·European Journal of Pharmacology·Teresa Mixcoatl-ZecuatlVinicio Granados-Soto
Apr 15, 2004·Immunology Letters·György PanyiRezso Gáspár
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fernanda B NunesJarbas R de Oliveira
Jun 1, 2001·Toxicon : Official Journal of the International Society on Toxinology·K G ChandyG A Gutman
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·M L GarciaG J Kaczorowski
Jan 13, 1998·Current Opinion in Biotechnology·M D Cahalan, K G Chandy
Oct 16, 2002·Vascular Pharmacology·Craig B Neylon
Oct 22, 2008·Nature Chemical Biology·Susy C Kohout, Ehud Y Isacoff
Dec 17, 2005·Nature Immunology·Elena M GalloGerald R Crabtree
Aug 24, 1999·British Journal of Pharmacology·H Rauer, S Grissmer
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zoltan TakacsSteve A N Goldstein
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J LeonardJ P Reuben
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Deutsch, L Q Chen
Jan 1, 1992·The Journal of General Physiology·S GrissmerM D Cahalan
Feb 1, 1992·The Journal of General Physiology·D Choquet, H Korn
May 1, 1992·The Journal of General Physiology·S C LeeC Deutsch
Dec 18, 1991·European Journal of Biochemistry·H Rehm
Jun 1, 1993·Alcoholism, Clinical and Experimental Research·D R OlesonR M Donahoe
Sep 21, 2004·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Rosane Vianna-Jorge, Guilherme Suarez-Kurtz
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BeetonE Béraud
Jun 30, 2009·Stem Cell Reviews and Reports·Sarah SundelacruzDavid L Kaplan
Sep 11, 2014·Journal of Molecular Biology·Prakash Subramanyam, Henry M Colecraft

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