Chasing the evidence: the influence of data segmentation on estimates of dynamic cerebral autoregulation.

Physiological Measurement
R B PaneraiT G Robinson

Abstract

Transfer function analysis (TFA) of dynamic cerebral autoregulation (dCA) requires smoothing of spectral estimates using segmentation of the data (SD). Systematic studies are required to elucidate the potential influence of SD on dCA parameters. Healthy subjects (HS, n = 237) and acute ischaemic stroke patients (AIS, n = 98) were included. Cerebral blood flow velocity (CBFV, transcranial Doppler ultrasound) was recorded supine at rest with continuous arterial blood pressure (BP, Finometer) for a minimum of 5 min. TFA was performed with durations SD = 100, 50 or 25 s and 50% superposition to derive estimates of coherence, gain and phase for the BP-CBFV relationship. The autoregulation index (ARI) was estimated from the CBFV step response. Intrasubject reproducibility was expressed by the intraclass correlation coefficient (ICC). In HS, the ARI, coherence, gain, and phase (low frequency) were influenced by SD, but in AIS, phase (very low frequency) and ARI were not affected. ICC was excellent (>0.75) for all parameters, for both HS and AIS. For SD = 100 s, ARI was different between HS and AIS (mean ± sdev: 5.70 ± 1.61 vs 5.1 ± 2.0; p < 0.01) and the significance of this difference was maintained for SD = 50 s and 25 s. Using SD =...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·R AaslidH Nornes
Jun 1, 1995·Stroke; a Journal of Cerebral Circulation·F P TiecksD W Newell
Aug 1, 1996·IEEE Transactions on Bio-medical Engineering·R B PaneraiD H Evans
Feb 12, 1998·The American Journal of Physiology·R ZhangB D Levine
Sep 25, 1998·Medical & Biological Engineering & Computing·R B PaneraiD H Evans
Nov 6, 1998·Stroke; a Journal of Cerebral Circulation·R B PaneraiD H Evans
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ronney B PaneraiJohn F Potter
Nov 29, 2007·Cardiovascular Engineering·Ronney B Panerai
Mar 20, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Arenda Hea van BeekRené Wmm Jansen
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Marcel J H AriesPatrick C A J Vroomen
Oct 12, 2013·Medical Engineering & Physics·Ronney B Panerai
Jul 12, 2014·Journal of Applied Physiology·Nicole S CoverdaleJ Kevin Shoemaker
Sep 6, 2014·Journal of Applied Physiology·Jasper VerbreeMatthias J P van Osch
Oct 10, 2014·Cerebrovascular Diseases Extra·Angela S M SalinetThompson G Robinson
Jan 20, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jurgen A H R ClaassenUNKNOWN international Cerebral Autoregulation Research Network (CARNet)
Feb 6, 2016·Stroke; a Journal of Cerebral Circulation·Hongyin MaYi Yang
Apr 20, 2016·Physiological Measurement·R B PaneraiT G Robinson
Aug 12, 2016·Physiological Measurement·Nikil PatelThompson G Robinson
Dec 9, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J R CaldasL A Hajjar
Mar 7, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Li XiongKa Sing Wong
Jul 12, 2018·Cerebrovascular Diseases Extra·Osian LlwydRicardo C Nogueira
Aug 18, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Angela Sm SalinetEdson Bor-Seng-Shu
Dec 14, 2018·Physiological Measurement·Marit L SandersJan Willem J Elting
May 19, 2019·Journal of the Neurological Sciences·Angela S M SalinetThompson G Robinson
Jul 30, 2019·Frontiers in Physiology·Marit L SandersJurgen A H R Claassen
Aug 23, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kannakorn IntharakhamThompson G Robinson

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