Chasing the golden egg: vaccination against poultry coccidiosis

Parasite Immunology
P A SharmanM Katrib

Abstract

Eimeria species, of the Phylum Apicomplexa, cause the disease coccidiosis in poultry, resulting in severe economic losses every year. Transmission of the disease is via the faecal-oral route, and is facilitated by intensive rearing conditions in the poultry industry. Additionally, Eimeria has developed drug resistance against most anticoccidials used today, which, along with the public demand for chemical free meat, has lead to the requirement for an effective vaccine strategy. This review focuses on the history and current status of anticoccidial vaccines, and our work in developing the transmission-blocking vaccine, CoxAbic (Netanya, Israel). The vaccine is composed of affinity-purified antigens from the wall-forming bodies of macrogametocytes of Eimeria maxima, which are proteolytically processed and cross-linked via tyrosine residues to form the environmentally resistant oocyst wall. The vaccine is delivered via maternal immunization, where vaccination of laying hens leads to protection of broiler offspring. It has been extensively tested for efficacy and safety in field trials conducted in five countries and involving over 60 million offspring chickens from immunized hens and is currently the only subunit vaccine against a...Continue Reading

Citations

Nov 19, 2013·Trends in Parasitology·Damer P Blake, Fiona M Tomley
Mar 8, 2014·Experimental Parasitology·Thierry Monney, Andrew Hemphill
Oct 8, 2013·Eukaryotic Cell·John SamuelsonPhillips W Robbins
Feb 27, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Makoto MatsubayashiNaotoshi Tsuji
May 11, 2010·Trends in Parasitology·Michael Wallach
Sep 1, 2014·Developmental and Comparative Immunology·Jipseol JeongWongi Min
Dec 3, 2014·Research in Veterinary Science·W C YangC L T Chang
May 27, 2014·Research in Veterinary Science·Wenyan ShiXiaomin Zhao
Apr 24, 2012·Current Opinion in Immunology·Ashley M Vaughan, Stefan H I Kappe
Sep 19, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Stephen J GoodswenJohn T Ellis
Feb 11, 2015·Vaccine·Michael P ReichelJohn T Ellis
May 28, 2013·The Korean Journal of Parasitology·Jinjun XuJianping Tao
Mar 19, 2015·BioMed Research International·Rosa Estela Quiroz-Castañeda, Edgar Dantán-González
Oct 11, 2016·Gastroenterology Research and Practice·Helieh S Oz
Oct 2, 2014·Revista brasileira de parasitologia veterinária = Brazilian journal of veterinary parasitology : Órgão Oficial do Colégio Brasileiro de Parasitologia Veterinária·Fagner Luiz da Costa Freitas
Feb 21, 2018·Poultry Science·Grace A AlbaneseBrian J Jordan

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