PMID: 16627998Apr 22, 2006Paper

Check, double check: the G2 barrier to cancer

Cell Cycle
Floris Foijer, Hein te Riele

Abstract

Loss of the G1/S checkpoint is recognized as a mandatory step in the development of cancer. Nevertheless, both in vivo and in vitro experiments have indicated that this condition highly sensitizes cells to apoptosis, e.g., primary mouse embryonic fibroblasts that lack the complete retinoblastoma suppressor gene family (TKO MEFs) massively die under mitogen-deprived conditions. The prevailing hypothesis therefore is that the increased proliferative capacity of cells that have lost the G1/S checkpoint becomes apparent by suppression of apoptosis. However, this view was recently challenged by the finding that suppression of apoptotic cell death in TKO MEFs did not allow unconstrained proliferation; instead, cells became arrested in G2. This mechanism, which is dependent on p53, provides yet another barrier to oncogenic transformation. Thus, progression to malignancy of Rb-deficient lesions by alleviation of G2 arrest may offer an alternative explanation for the synergism between loss of Rb and p53 in tumorigenesis.

Citations

Feb 11, 2010·Anti-cancer Drugs·Venkateswaran SubramaniamSerge Jothy
Jun 9, 2006·Cell Division·Floris Foijer, Hein Te Riele
Jun 6, 2009·European Journal of Clinical Nutrition·T A WoyengoP J H Jones
Nov 15, 2007·Cytogenetic and Genome Research·C J YeH H Q Heng
Apr 27, 2013·The Journal of Nutritional Biochemistry·Chun-Yin HuangMing-Fen Lee
Oct 4, 2011·Pulmonary Pharmacology & Therapeutics·Jin Won HuhYun-Song Lee
Sep 16, 2008·The International Journal of Biochemistry & Cell Biology·Lorena TravagliniClara Nervi
Aug 19, 2008·Biochimica Et Biophysica Acta·Floris FoijerPeter K Sorger
Jun 14, 2008·Journal of Ethnopharmacology·J W M Yuen, M D I Gohel
Nov 13, 2007·Biochimica Et Biophysica Acta·Romina MaroneMatthias P Wymann
Feb 3, 2007·Molecular Nutrition & Food Research·Peter G Bradford, Atif B Awad
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Jun 29, 2016·The Journal of Pharmacy and Pharmacology·Mariana F da MotaMarize C Valadares
May 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin LiuHaitao Zhu
Aug 19, 2007·Oncogene·F FoijerH Te Riele
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Jun 25, 2009·Cancer Research·Cara J LauJosephine Nalbantoglu

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